·糖尿病与神经疾病·

　　【摘要】 目的 探讨T2DM患者血清β-淀粉样蛋白40(Aβ1-40)水平与轻度认知功能障碍(MCI)的关系。 方法 用蒙特利尔认知评估(MoCA)北京版量表测评糖尿病患者的认知功能，并检测其血清Aβ1-40水平。 结果 MCI组的糖尿病病程、FPG(9.20±3.35)mmol/L、HbA1c(7.27±1.7)%、Aβ1-40[224.83(124.86～273.39)pg/ml]高于对照组(P<0.05)。多元回归分析显示,FPG、C-P和Aβ1-40(β=-0.23，P=0.02)是MoCA评分的影响因素，MoCA(β=-0.22，P=0.04)评分和HbA1c(β=0.27，P=0.01)是Aβ1-40的影响因素。结论Aβ1-40升高可能是T2DM患者发生认知功能障碍的危险因素。

　　【关键词】 糖尿病，2型;轻度认知功能障碍;β-淀粉样蛋白40;蒙特利尔认知评估量表

Association of β-amyloid peptide 40 with mild cognitive impairment in patients with type 2 diabetes mellitus JIANG Xiao-zhen, ZHAO Xiao-hui, CHEN Rui-hua, et al. Department of Endocrinology, Pudong New Area People's Hospital, Shanghai 201200, China

　　【Abstract】Objective To analyze the relationship between the serum β-amyloid peptide 40 (Aβ1-40) levels and mild cognitive impairment (MCI) in the T2DM patients. Methods Montreal Cognitive Assessment (Beijing Version) was applied for determination of cognitive function of the subjects. Ninety-two T2DM patients with MCI (MCI group) and 40 with normal cognitive function (control group) were enrolled in this study. ELISA was applied to measure the serum Aβ1-40 concentrations of the subjects. Results The duration of T2DM and the levels of FPG (9.20±3.35)mmol/L, HbA1c (7.27±1.74)%, and Aβ1-40 [224.83 (124.86～273.39)pg/ml] in the MCI group were significantly higher than those in the control group(P<0.05). The multivariate Logistic analysis showed that the FPG, C-P, and Aβ1-40 (β=-0.23, P=0.02) were the influencing factors of MoCA score. MoCA (β=-0.22, P=0.04) score and HbA1c (β=0.27, P=0.01) were the influencing factors of Aβ1-40. Conclusion Elevated Aβ1-40 could be a risk factor of MCI incidence in the T2DM patients.

　　【Key words】Diabetes mellitus, type 2; Mild cognitive impairment (MCI); β-amyloid peptide 40 (Aβ1-40); Montreal Cognitive Assessment