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胰升血糖素样肽-1受体激动剂对周围神经系统的作用

来自:中国糖尿病杂志  编辑:郝明 匡洪宇|点击数:|2013-09-26

  ·文献综述·

  【摘要】 胰升血糖素样肽-1(GLP-1)是肠道因进食而分泌的促胰岛素分泌肽,是最早发现的胰升血糖素样肽-1受体(GLP-1R)激动剂。GLP-1R及GLP-1在神经系统都有广泛的表达,多项体内与体外实验证明GLP-1R可以促进神经细胞的存活,并且GLP-1及其类似物有营养保护神经等多种生理作用。GLP-1R及其激动剂在外周神经系统功能的多样性具体为周围神经保护作用、通过周围神经调节血糖、影响食欲、调节周围神经兴奋性等。GLP-1R激动剂可能会成为一种新型神经保护药物,它对周围神经的保护作用可以用于糖尿病周围神经病变(DPN)等周围神经变性疾病的治疗。

  【关键词】 胰升血糖素样肽-1受体;胰升血糖素样肽-1;神经系统;糖尿病周围神经病

Effect of glucagon like peptide-1 receptor agonists on the peripheral nervous system HAO Ming, KUANG Hong-yu. Department of Endocrinology, The First Hospital Affiliated to Harbin Medical University, Harbin 150001, China

Corresponding author:KUANG Hong-yu,E-mail:kuangzou2010@yahoo.com.cn

  【Summary】 The glucagon-like peptide-1 (GLP-1) was found at the earliest the GLP-1R agonists. Secreted by intestine for eating, it can promote insulin secretion. GLP-1R and GLP-1 have abundant expressions in the nervous system. Experiments in vitro and in vivo have proved that GLP-1R can prolong the nerve cells’ lifetime, and GLP-1 has nourishing and protecting functions for nerve. The functional diversity of GLP-1R and its agonists for peripheral nerve include protecting peripheral nerve and adjusting its excitement and regulating blood glucose and affecting appetite through peripheral nerve. GLR-1R agonists will probably become a promising drug used for protecting nervous system. Its protective action for peripheral nerve can be adopted in the treatment of peripheral neuropathy, such as diabetic peripheral neuropathy.

  【Key words】 Glucagon-like peptide-1 receptor;Glucagon-like peptide-1;Nervous system;Diabetic perineuropathy

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