·糖尿病与神经疾病·

　　【摘要】 目的 评价T2DM合并抑郁状态患者的人格特征与社会支持状况，探讨T2DM患者合并抑郁状态患者脂肪因子变化情况。 方法 选择新诊断T2DM患者181例，采用抑郁自评量表进行评分，分为抑郁状态组(DM-D)125例与非抑郁状态组(T2DM)56例，分别进行“艾森克人格量表”和“社会支持量表”评价。测定糖脂代谢指标、皮质醇、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、内脂素和脂联素(APN)。 结果 T2DM合并抑郁患病率为69.06%，与T2DM组相比，DM-D组神经质[(4.39±2.27 )vs(1.84±1.97)]得分高、内-外向[(7.73±3.14)vs(9.09±2.34)]和客观支持[(9.48±3.35) vs (11.06±3.12)]得分低。与T2DM组比，DM-D组血浆IL-6、TNF-α和内脂素水平均增高(P均<0.05)，脂联素水平降低。SDS评分与内脂素、IL-6、TNF-α神经质呈正相关关系，与脂联素、内外向、客观支持呈负相关关系。 结论 T2DM易合并抑郁，内向人格、神经质人格、社会客观支持度低者易导致抑郁状态，抑郁患者体内炎性应激和IR更高。

　　【关键词】 糖尿病,2型;抑郁状态;人格特征;社会支持;内质素;脂联素

Assessment of diabetics accompanied with depression HOU Ningning, SUN Jinzhi, LIU Yan, et al. Department of Endocrinology, The Affiliated Hospital of Weifang Medical College, Weifang 261041, China

Corresponding author: SUN Xiao-dong, E-mail: sxdfriend@sina.com

　　【Abstract】 Objective To evaluate the personality characteristics and social support and to explore the changes of adipocytokines of the T2DM patients accompanied with depression. Methods The 181 newly diagnosed type 2 diabetes inpatients, according to the depression self rating scale, were divided into depression group (DM-D group, 125 cases) and the non-depression group (T2DM group, 56 cases). They were evaluated with the "Eysenck personality" questionnaire and "social support" scale. The measurement of glycol- and lipo-metabolism, cortisol, IL-6, TNF-α, visfatin and adiponectin was done for analysis. Results The prevalence of T2DM accompanied with depression was 69.06%. Compare with the T2DM group, there was the higher score of neuroticism (4.39±2.27 vs 1.84±1.97) and lower scores of intra- and extra-version (7.73±3.14 vs 9.09±2.34) and objective support (9.48±3.35 vs 11.06±3.12) in the DM-D group. Compare with the T2DM group, there was the increase of IL-6, TNF-α, and visfatin and the decrease of adiponectin in the DM-D group. The SDS score was positively correlated with visfatin, TNF-α, and neuroticism, but negatively correlated with adiponectin, intra- and extra-version, and objective support. Conclusions T2DM is likely to be accompanied with depression. Those who are in intra-version and neuroticism personality and with low social support are more easily to be in the depressed state. The depression patients have higher levels of inflammatory stress and insulin resistance.

　　【Keywords】 Diabetes mellitus, type 2; Depression state; Personality characteristics; Social support; Visfatin; Adiponectin