·文献综述·

　　【摘要】糖尿病患者易发生抑郁障碍，而IR是公认的T2DM发生机制之一。IR与抑郁症具有相互重叠的病理生理学机制，两者之间互相关联。本文通过阅读大量近年来国内外发表的文献，对IR与抑郁症的相关性及其可能的机制与治疗方法展开综述。

　　【关键词】 抑郁症;胰岛素抵抗;2型糖尿病

Depression and insulin resistance LI Guang-qi, LIU Yan-jun. Department of Endocrinology, The 306 Hospital of the People's Liberation Army, Beijing 100101, China

　　【Summary】 Diabetes patients are prone to have depression, while insulin resistance is well known as one of the mechanisms of development of T2DM. Depression and insulin resistance have overlapping pathological and physiological mechanisms. They are mutually connected with each other in different levels. In this review, by reading a significant amount of recently published literatures, we discussed the correlations between depression and insulin resistance and the possible mechanisms of the interaction of these two and the treatment of their combined symptoms.

　　【Key word】Depression; Insulin resistance; Diabetes mellitus, type 2