·糖尿病与神经疾病·

　　【摘要】 目的 观察羟苯磺酸钙联合单唾液酸四己糖神经节苷脂钠治疗老年糖尿病周围神经病变(DPN)的临床疗效。 方法 将纳入研究的DPN患者随机分为试验组67例和对照组64例。在控制血糖基础上，试验组予单唾液酸四己糖神经节苷脂钠加羟苯磺酸钙治疗;对照组予甲钴胺注射液治疗，8周后对研究对象进行有效性评估。 结果 ⑴治疗8周后，试验组密歇根糖尿病神经病变评分量表(MDNS)及密歇根神经病变筛查量表(MNSI)评分较对照组及试验前降低(P均<0.05);⑵治疗8周后，试验组冷感觉阈值温度(26.33±1.07)℃较对照组(23.17±1.21)℃及试验前(21.64±1.12)℃升高。试验组热感觉、冷痛觉阈值温度分别较对照组及试验前降低(P均<0.05);⑶治疗8周后，试验组正中神经运动神经传导速度MCV、腓总神经MCV、正中神经感觉神经传导速度SCV及腓总神经MCV均较对照组及治疗前升高(P均<0.05)。 结论 单唾液酸四己糖神经节苷脂钠联合羟苯磺酸钙治疗DPN取得较好的疗效，值得在老年人中推荐使用。

　　【关键词】糖尿病周围神经病变;老年;单唾液酸四己糖神经节苷脂钠;羟苯磺酸钙

Effects of calcium dobesilate dispersible in combination with monosialotetrahex–osylganlioside sodium on elderly diabetic peripheral neuropathy SHEN Xiao-zhu, XU Bao-luan, Dong Lan, et al. Department of Geriatrics, Lianyungang The Second People’s Hospital, Lianyungang 222006, China

　　【Abstract】Objective To observe the efficacy of calcium dobesilate dispersible used together with monosialotetrahexosylganlioside sodium on elderly diabetic peripheral neuropathy (DPN). Methods The 157 DPN patients, aged ≥ 60 years, were randomized into the experiment group (n=67) and the control group (n=64). All subjects were basically treated for plasma glucose control. The experimental group was treated with monosialotetrahexosylganlioside sodium and calcium dobesilate dispersible. The control group was treated with methylcobalamin injection. After treatment for 8 weeks, the assessment on the therapeutic effect was done for evaluation. Results After treatment, ⑴. the Michigan diabetic neuropathy score (MDNS) and Michigan neuropathy screening instrument (MNSI) scores of the experiment group (15.16±5.46, 2.53±1.12) were significantly lower than the control group (19.87±4.65, 4.81±0.98) and before treatment (20.45±4.78, 5.37±1.63), (p<0.05); (2). the cold sensation threshold of the experiment group (26.33±1.07℃) was significantly higher than the control group (23.17±1.21℃) and before treatment (21.64±1.12℃), while the thermal sensation and cold pain of the experiment group (38.73±1.13℃, 12.11±1.06℃) were significantly lower than the control group (41.35±1.56℃, 15.37±1.65℃) and before treatment (43.16±1.38℃, 16.16±1.16℃); and (3) the motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) of median nerve and peroneal nerve in the experiment group (44.36±7.21m/s, 41.78±5.57m/s, 40.18±5.09m/s, 37.23±6.27m/s) were significantly higher than in the control group (40.94±5.29m/s, 37.08±6.46m/s, 33.15±3.56m/s, 32.56±5.73m/s) and before treatment (40.17±5.63 m/s, 36.13±4.22 m/s, 34.43±5.28 m/s, 32.15±5.51 m/s), (p<0.05). Conclusions A good therapeutic effect is achieved in the treatment of elderly DPN with calcium dobesilate dispersible and monosialotetrahexosylganlioside sodium in combination. It is worth spreading in clinical practice.

　　【Key words】Diabetic peripheral neuropathy; Elderly; Monosialotetrahexosylganlioside sodium; Calcium dobesilate dispersible