病例报告

　　【摘要】 回顾分析2例经病理检查确诊肺型、鼻脑型毛霉菌合并糖尿病患者的临床特征。其中，1例为糖尿病合并肺型毛霉菌患者，表现为胸痛、咯血，右上肺肿块穿刺活检示形态符合毛霉菌，采用两性霉素B及手术治疗治愈。1例为糖尿病合并鼻脑型毛霉菌病患者，表现为头痛、鼻腔内黑色干酪样物，最后偏瘫、死亡，鼻腔肿物病理检查见毛霉菌团块及菌孢，经手术及氟康唑治疗无效后死亡。毛霉菌病罕见且易继发于糖尿病等免疫力低下疾病，病情进展迅速，需尽快诊断及治疗。

　　【关键词】糖尿病;毛霉菌病;两性霉素B

　　【Summary】 This article reviewed the clinical features in two diabetes cases complicated with nasal-brain mucormycosis by pathology and pulmonary mucormycosis. In one patient with diabetes combined with pulmonary mucormycosis, manifestations of chest pain and hemoptysis, the right upper lung biopsy tip morphology was consistent with Mucor, successfully cured with amphotericin and operation treatment. The other patient with diabetes-complicated nasal mucormycosis with headache and nasal cavity clump, showed black caseous matter, finally hemiplegia. A nasal cavity tumor was proved by pathological examination. After treatment with fluconazole and operation, the patientdied. Mucormycosisis rare and may be secondary to diabetes and hypoimmunity disease. It needs rapid diagnosis and treatment.

　　【Key words】Diabetes mellitus;Mucormycosis;Amphotericin B