·文献综述·

　　【摘要】 二甲双胍作为T2DM患者的一线治疗药物已被广泛共识，但T2DM是一种进行性疾病，起始采用二甲双胍单药治疗的患者，随时间的推移和病程的进展，常需联合其他口服降糖药物如磺脲类、格列奈类、噻唑烷二酮衍生物(TZDs)、α葡萄糖苷酶抑制剂(AGDI)、二肽基肽酶-4(DPP-4)抑制剂、胰升血糖素样多肽-1(GLP-1)受体激动剂或胰岛素制剂来控制血糖。本文就二甲双胍与其他降糖药物联用的临床疗效研究进展作一综述。

　　【关键词】 二甲双胍;联合治疗;降糖药物;疗效

　　【Abstract】 Metformin was widely recommended as a first-line drug for patients with type 2 diabetes mellitus(T2DM). However, studies have shown that patients who start metformin as monotherapy often required additional agents to maintain glycaemic control with the natural progression of T2DM. Anti-diabetic agents may be used in combination with metformin, including sulfonylureas, glinides, thiazolidinediones(TZDs), α-glucosidase inhibitor(AGDI), dipeptidyl peptidase-4 inhibitor(DPP-4) and glucagon-like peptide 1(GLP-1) or insulin. This paper mainly reviews the recent studies about the therapeutic effect of metformin in combination with other anti-diabetic agents.

　　【Key words】 Metformin; Combination therapy; Hypoglycemic agent; Efficacy