文献综述　　

　　【摘要】糖尿病患者合并肺部疾病时肺功能改变主要表现为肺通气功能降低、肺弥散功能降低、肺支气管张力降低和呼吸肌功能异常，其发病机制主要包括组织蛋白非酶糖基化、氧化应激、IR、局部防御功能改变和自主神经病变。糖尿病是肺功能降低发生的独立危险因素，肺功能降低是糖尿病发生的独立预测因素。糖尿病患者肺功能变化与年龄、病程、血糖水平和并发症相关。

　　【关键词】糖尿病;肺功能;肺弥散功能;肺通气功能

　　【Summary】 When accompanied with pulmonary disease, the lung functions of diabetic patients usually represent decreases of diffusing capacity, ventilation function, bronchomotor tone and respiratory muscles. The mechanisms of lung damage may include non-enzymatic glycosylation of proteins, oxidative stress, IR, local defensive ability change, and autonomic neuropathy. Diabetes mellitus is a risk factor for lung function damage, and lung function damage is an independently predictive factor of diabetes mellitus. The change of lung function in diabetic patients is associated with age, duration, blood glucose level and complications.

　　【Key words】 Diabetes mellitus;Pulmonary disease;Pulmonary diffusion function;Pulmonary ventilation function