·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 研究T2DM患者血清胰岛素样生长因子结合蛋白7(IGFBP7)与IR的相关性。方法 选取新诊断T2DM患者(T2DM组)137例和健康体检者(NC组)96名，测定两组FPG、FIns、血脂、C-RP、肿瘤坏死因子-α(TNF-α)和IGFBP7。结果 T2DM组除TC和LDL-C外，其余指标与NC组比较差异有统计学意义(P<0.05)。按T2DM组IGFBP7四分位数将其分成4组(Q1~4)，各组间年龄、BMI、CRP、TNF-α、FIns、HOMA-IR和HOMA-IS差异有统计学意义(P<0.05);新诊断T2DM患者IGFBP7与年龄、BMI、C-RP、TNF-α、FINS和HOMA-IR呈正相关性(r=0.264、0.173、0.255、0.227、0.192、0.325，P<0.05)，与HOMA-IS呈负相关性(r=-0.324，P<0.01)。年龄、C-RP、TNF-α和HOMA-IR是影响新诊断T2DM患者IGFBP7水平的独立因素 (标准化β=0.318、0.186、0.239、0.255，P<0.05)。结论 新诊断T2DM患者IGFBP7与年龄、C-RP、TNF-α和HOMA-IR密切相关。

　　【关键词】 胰岛素样生长因子结合蛋白7;糖尿病，2型;胰岛素抵抗

Association of increased serum IGFBP7 with insulin resistance in T2DM YUAN Lei, WANG Jian-guo, ZUO Shu-guang, et al. Laboratory of Molecular Medicine, Luohe Medical College, Luohe 462002, China

Corresponding author: XU Wan-ling, E-mail: fzyx_yl@163.com

　　【Abstract】 Objective To investigate the association of increased serum insulin-like growth factor binding protein 7 (IGFBP7) with insulin resistance in T2DM. Methods The 137 newly diagnosed T2DM patients and 96 normal controls (NC) were involved in the study. Levels of FPG, blood lipids, fasting insulin (FIns), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and insulin-like growth factor binding protein 7 (IGFBP7) of the two groups were measured. Results In the T2DM group, except total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), other indices were statistically different from those in the normal controls (P<0.05). The T2DM group was subdivided into four groups according to quartiles of IGFBP7. The age, BMI, CRP, TNF-α, FIns, HOMA-IR, and HOMA-IS were significantly different among the 4 groups. IGFBP7 of the T2DM patients was correlated positively with age, BMI, CRP,TNF-α, FIns, and HOMA-IR (r=0.264, 0.173, 0.255, 0.227, 0.192, 0.325, P<0.05), and negatively with HOMA-IS (r=–0.324, P<0.01). Age, CRP,TNF-α, and HOMA-IR stood as independent variables of IGFBP7 in T2DM patients (standardized β = 0.318, 0.186, 0.239, 0.255, P<0.05). Conclusion IGFBP7 is closely related to age, CRP, TNF-α and insulin resistance in T2DM patients.

　　【Key words】Insulin-like growth factor binding protein 7 (IGFBP7); Diabetes mellitus, type 2; Insulin resistance (IR)