·文献综述·

　　【摘要】 DM并发症是DM患者致死致残的主要原因，其病理生理机制中涉及PKC信号途径的激活。研究表明，PKC-δ亚型的激活及其产生的后续效应参与了DM大血管及微血管病变的发生发展。在细胞凋亡、增殖及迁移、调节血管功能相关的细胞因子及细胞外基质方面，PKC-δ起到了关键的作用。故开发针对PKC-δ的特异性药物具有很大的前景。

　　【关键词】 蛋白激酶C-δ;糖尿病并发症

PKC-δ: A new target for prevention of diabetic vascular complications SUN Fang, ZHOU Bo. Department of Hypertension and Endocrinology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China

　　【Summary】 Diabetes complication is the main reason for death and disability in diabetics. Its pathophysiological mechanism involves the activation of PKC signaling pathway. It is reported that the activation of PKC-δ and its follow-up effect triggered the micro- and macro-vascular complications by participating in cell apoptosis, proliferation and migration, regulating the associated cytokine, and extracellular matrix, so the therapeutic drug targeted at PKC-δ is very potential.

　　【Key words】Protein kinase C (PKC); Diabetes complication