·糖尿病与妊娠·

　　【摘要】 目的 观察妊娠相关血浆蛋白A(PAPP-A)和白介素6(IL-6)在高血压前期(PH)合并IGT患者中的水平变化，探讨其之间的关系。 方法 入选PH患者100例，其中合并IGT(PH +IGT)者50例，糖耐量正常(PH+NGT)者50名。采用ELISA法测血浆中PAPP-A、IL-6含量。 结果 PH+IGT组PAPP-A和IL-6水平高于PH+NGT组[PAPP-A(12.43±3.65vs 9.5±3.39 ) mU/L，IL-6 (101.64±19.13vs87.56±17.32) ng/L,P<0.05] 。多因素logistic回归分析显示，PAPP-A和IL-6是IGT合并高血压前期危险因素的一部分。 结论 高血压前期合并IGT患者PAPP-A和IL-6 水平增高。

　　【关键词】高血压前期;糖耐量减低;妊娠相关血浆蛋白A;白介素6

Levels of pregnancy associated plasma protein A an d iterleukin 6 in prehypertension patients with impaired glucose tolerance JIANG Wen-yan， WANG Xi-zhu，SONG Qiao-feng，et al.Department of Cardiology , People’s Hospital of Tangshan，Hebei 063000

　　【Abstract】 Objective To study the levels of pregnancy associated plasma protein A (PAPP-A) and interleukin 6 (IL-6) in patients with prehypertension (PH) and IGT. Methods We recruited 100 PH patients，50 with normal glucose tolerance ( NGT ) and 50 with IGT. The levels of pregnancy associated plasma protein A and interleukin 6 were determined by ELISA. Results The levels of PAPP-A and IL-6 in patients with PH and IGT were higher than patients with PH and NGT [PAPP-A (12.43±3.65 vs 9.5±3.39) mIU/L，IL(101.64±19.13 vs 87.56±17.32) ng/L，all P<0.05].Multivariate analysis showed PAPP-A，IL-6，BMI and systolic blood pressure were predisposing risk factors for perhypertensive patients with IGT. Conclusion PAPP-A and IL-6 are enhanced in prehypertension with IGT.

　　【Key words】Prehypertension;Impaired glucose tolerance;Pregnancy associated plasma protein A;Interleukin 6