•糖尿病与脂质代谢•

　　新诊断2型糖尿病患者合并脂代谢紊乱及脂肪肝的探讨

　　郭玫 李红梅 刘瑛

　　【摘要】 目的 探讨新诊断T2DM患者脂代谢紊乱的临床特征及其与IR和非酒精性脂肪肝(NAFLD)发病的关系。 方法 110例新诊断T2DM患者分为血脂正常(Con)组和血脂异常组(HTG组，HTC组，Mix组)。用统计学方法分析研究血脂紊乱与BMI，Ins, C-P，HbA1c, HOMA-IR及有无NAFLD的关系。 结果 被研究者中合并脂代谢紊乱率64.50%(71例);合并NAFLD率57.30% (63例)。BMI,空腹C-P在HTG组和Mix组显著高于Con组，差异有统计学意义(P<0.05)。BMI及TG为发生NAFLD的独立危险因素(P<0.05)。 结论 高TG和/或NAFLD的存在为个体IR的标志。 控制血脂水平及脂肪肝对延缓糖尿病并发症的发生发展与控制血糖同样重要。

　　【关键词】 糖尿病,2型;脂代谢紊乱;胰岛素抵抗;脂肪肝

　　Study on the newly diagnosed T2DM patients with lipometabolism disturbance and fatty liver GUO Mei, LI Hong-mei, LIU Ying. Department of General Medicine, Ningxia People’s Hospital, Yinchuan 750001, China

　　【Abstract】 Objective To explore the clinical characteristics of newly diagnosed T2DM patients with lipometabolic disturbance and their relations with insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Methods The 110 newly diagnosed T2DM patients were divided into normal blood lipid group (control group) and abnormal blood lipid groups (including hypertriglyceridemia group, high total cholesterol group, and mix group with both HTG and HTC). The relation of the lipometabolic disturbance with BMI, serum insulin, and C-P, HbA1c, HOMA-IR, and the incidence of NAFLD was observed and analyzed by statistical methods. Results Incidence of lipometabolic disturbance and NAFLD in the subjects was 64.50% (71 cases) and 57.30% (63 cases) respectively. The BMI and fasting C-P were significantly higher in both HTG group and mix group than in control group (P<0.05). The incidence of NAFLD was independently correlated with BMI and HTG (P<0.05). Conclusion The HTG and/or NAFLD are markers of IR. The control of blood lipid and NAFLD are as important as the control of blood glucose for postponing the natural development of diabetic complications.

　　【Key words】 Diabetes mellitus，type2; Lipometabolism disturbance; Insulin resistance; Fatty liver