·文献综述·

　　成骨细胞在维持机体糖稳态中调节作用的研究

　　闫彩凤 向红丁

　　【提要】 成骨细胞特异性表达的ESP基因通过控制骨钙素的生物活性来参与对糖稳态的调节，成骨细胞ESP基因缺陷可以保护小鼠免于发生糖尿病和肥胖;成骨细胞交感神经通路是瘦素调节胰岛素分泌的主要机制。揭示了成骨细胞在维持机体糖稳态中的重要作用。

　　【关键词】 成骨细胞;骨钙素;ESP基因;瘦素

　　Study on osteoblasts maintaining glucose homeostatsis YAN Cai-feng, XIANG Hong-ding. Department of Endocrinology, Clinical Medical College of Yangzhou University, Yangzhou 225001, China

　　【Summary】 ESP is an osteoblasts-specificity gene. It can control the activation of osteocalcin to partake the regulation of glucose metabolism. Osteoblast ESP gene deficiency protects mice from incidence of diabetes and obesity. Leptin-dependent sympathetic suppression of insulin secretion occurs through the osteoblasts. Conversely, osteocalcin, an osteoblast-derived signaling molecule, regulates glucose metabolism resulting in increased insulin secretion and sensitivity. Osteoblast plays a very important role in maintaining glucose homeostatsis.

　　【Key words】 Osteoblast; Osteocalin; ESP; Leptin