【摘要】  目的  探讨影响住院T2DM患者左心室舒张功能不全（LVDD）的相关因素。方法  连续收集1013例住院T2DM患者的临床资料，采用超声心动图检测左心室舒张功能。Logistic回归分析LVDD的影响因素。 结果  51.3%的患者存在LVDD。LVDD较非LVDD组年龄[（49.0±12.1) vs （61.3±10.0）岁]、中位糖尿病病程（7.0 vs 11.0年）、WC [(93.6±11.0) vs （95.4±10.7)cm]、SBP[(128±16) vs （134±18)mmHg]、Cr[(61.4±15.7) vs （68.0±30.0)  µmol/L]、尿白蛋白/肌酐（UAlb/Cr）（4.3 vs 6.2 mg/g）升高(P＜0.05)；Logistic回归分析显示,年龄、WC、SBP、LDL-C 、Cr与LVDD独立相关[OR(95%CI)=1.110(1.091～1.129)、1.023(1.007～1.039)、1.013(1.004～1.022)、1.264(1.052～1.519)、1.010（1.001～1.020），P<0.05]；在无高血压史患者中，随HbA₁c增高，LVDD患病风险增高，但差异无统计学意义（P=0.055）。 结论  住院T2DM患者中，LVDD患病率高，年龄、WC、SBP、LDL-C和Cr增高与LVDD独立相关。

【关键词】糖尿病，2型；左室舒张功能不全;住院患者

Risk factors for left ventricular diastolic dysfunction in type 2 diabetic patients admitted to hospital  CHEN Jing，ZHOU Xiang-hai，PANG Meng-duan，et al, Department of Endocrinology and Metabolism, Peking University, People's Hospital，Beijing 100044,China

Corresponding author: Zhou Xianghai，E-mail：xianghai_zhou@163.com

【Abstract】 Objective  To investigate risk factors for left ventricular diastolic dysfunction (LVDD) in type 2 diabetic patients admitted to hospital.  Methods Clinical data of 1013 patients with type 2 diabetes admitted to hospital were collected consecutively. Echocardiography was used to measure LVDD. Logistic regression analysis was used to identify associated factors for  LVDD.  Results 51.3% of the patients had LVDD. Age [(49.0±12.1) vs (61.3±10.0) years],  duration of diabetes (median duration 7 vs. 11 years), WC [(93.6±11.0) vs (95.4±10.7)cm], systolic blood pressure (SBP) [(128±16) vs (134±18)mmHg] , serum creatinine  (Cr) [(61.4±15.7) vs (68.0±30.0)µmol/L], and urinary albumin-to-creatinine ratio (UACR) (6.2 vs 4.3 mg/g) were higher in patients with LVDD than in patients without LVDD (P<0.05). Logistic regression analysis showed that age WC, SBP, LDL-C and Cr[OR(95% CI): 1.110(1.091～1.129), 1.023(1.007～1.039), 1.013(1.004～1.022),1.264(1.052～1.519), 1.010(1.001～1.020);P<0.05] were independent risk factors for LVDD. In patients without hypertension, there was a borderline significant association between HbA1c and the presence of LVDD (P=0.055). Conclusion There is a high prevalence of LVDD in type 2 diabetic patients admitted to hospital. Age, WC, SBP, LDL-C and Cr are independently associated with LVDD.