【摘要】  目的  观察不同血糖水平血清脂肪细胞脂肪酸结合蛋白（A-FABP）水平，探讨其与IR的相关性。 方法  选取NGT组55名、IGT组53例及T2DM组56例，测定各组血清A-FABP、FPG、2 hPG、TC、TG、FIns等指标，计算BMI，WHR及胰岛素抵抗指数（HOMA-IR），分析A-FABP与IR的相关性。 结果 T2DM组血清A-FABP水平高于IGT组和NGT组[（71.14±10.03）vs（36.69±8.01）vs（19.49±2.98）mg/L，P<0.05]。相关分析显示，血清A-FABP水平与BMI、WHR、TC、TG、HDL-C、LDL-C、HbA₁c、2 hPG、高敏C反应蛋白(hsC-RP)、HOMA-IR相关（r=0.739、0.320、0.202、0.213、－0.695、0.248、0.842、0.441、0.354、0.695，P<0.05或P<0.01）。多元回归逐步分析显示，BMI、WHR、HbA₁c、HOMA-IR是影响血清A-FABP的独立危险因素(t=2.621、4.461、7.362、3.875，P<0.05)。  结论  A-FABP与IR关系密切，随着IR程度的加重，A-FABP水平逐渐升高。

【关键词】脂肪细胞脂肪酸结合蛋白；胰岛素抵抗；糖尿病，2型

Serum adipocyte-fatty acid binding protein level and its clinical value in patients with abnormal glucose tolerance  YANG Hua, YANG Xiao-dong，RAO Li-hua，et al.Department of Clinical Laboratory,Renhe Hospital of Three Gorges University,Yichang 443001,China

【Abstract】 Objective To observe serum adipocyte-fatty fatty acid binding protein (A-FABP) level and its association with insulin resistance in patients with different glucose tolerance.  Methods  A total of 164 patients were enrolled in this study and divided into three groups: normal glucose tolerance (NGT group, n=55), impaired glucose tolerance (IGT group, n=53) and type 2 diabetes mellitus (T2DM group, n=56). A-FABP, FPG, 2 hPG, TC, TG, FIns were tested in all subjects. BMI, WHR and HOMA-IR were calculated and the relationship between A-FABP and IR was analyzed.   Results   A-FABP level was higher in T2DM group than in IGT and NGT group [（71.14±10.03）vs（36.69±8.01）vs（19.49±2.98）mg/L，P<0.05]. Association analysis showed that serum A-FABP was positively correlated with BMI、WHR、TG、TC、LDL-C、HbA₁c、2 hPG、hsC-RP and HOMA-IR（r=0.739，0.320，0.202，0.213，0.248，0.842，0.441，0.354，0.695, P<0.05 or P<0.01）,but was negatively correlated with HDL-C（r=－0.695,P<0.01）. Multiple regression analysis showed that BMI、WHR、HbA₁c、HOMA-IR were independent influencing factors for A-FABP (t=2.621，4.461，7.362，3.875，P<0.05).  Conclusion  A-FABP is closely related to IR. The level of A-FABP rises with the increase of IR severity.

【Key  words】Adipo-cyte fatty acid binding(A-FABP)；Insulin resistance（IR）；Diabetes mellitus，type 2