【摘要】  目的  研究T2DM患者中性粒细胞/淋巴细胞比值(NLR)与踝肱指数（ABI）的关系，分析NLR对T2DM下肢血管病变的临床价值。 方法 选取198例T2DM患者，依据ABI结果分为外周血管病变组（PAD，ABI＜0.9）66例和无外周血管病变组（Non-PAD，ABI≥0.9）132例，比较两组NLR的差异。   结果   PAD组较Non-PAD组NLR升高[(1.78±0.61) vs (2.13±0.80),P=0.002]。相关分析显示，NLR与ABI水平呈负相关(r=-0.224,P<0.01)；二元Logistic回归分析结果显示，HbA₁c、NLR和C-RP是下肢动脉病变的危险因素。  结论  NLR是T2DM患者下肢动脉病变的危险因素，对T2DM患者下肢血管病变有提示意义。

【关键词】中性粒细胞/淋巴细胞比值；踝肱指数；糖尿病下肢血管病变；糖尿病，2型

 Association analysis between neutrophil/lymphocyte ratio and ankle brachial index in patients with T2DM LIANG Ru-yu，LI Rong-dong, OUYANG-yi,et al.Department of Endocrinology, Zhujiang Hospital, Southern Medical University，Guangzhou 510280，China

Corresponding author：HE Lei，E-mail：765139701@qq.com

【Abstract】  Objective To investigate the association between neutrophil-lymphocyte ratio (NLR) and ankle brachial index (ABI) in patients with T2DM and evaluate the clinical value of NLR on peripheral arterial disease (PAD).  Methods  A total of 198 T2DM patients were enrolled in this study and divided into two groups according to their ABI results: PAD group (ABI<0.9, n=66), and non-PAD group (ABI≥0.9, n=132). NLR was compared between the two groups.  Results  NLR was significantly higher in PAD group than in non-PAD group [(1.78±0.61) vs (2.13±0.80),P=0.002].Association analysis showed that NLR was negative correlated with ABI(r=-0.224,P<0.01).Binary logistic regression analysis showed that NLR, HbA₁c and C-RP were risk factors for PAD [OR(95%CI): 2.232(1.225~4.067), 1.553(1.193~2.021), 1.771(1.224~2.520); P<0.05].  Conclusion  NLR is a risk factor for PAD and may play a part in T2DM patients with PAD.

【Key Words】Neutrophil/lymphocyte ratio（NLR）; Ankle brachial index（ABI）; Peripheral arterial disease(PAD); Diabetes mellitus，type 2