【摘要】  目的  观察T1DM患者血清内脂素(visfatin)水平的变化，探讨其与T1DM患者糖脂代谢的相关性。  方法  采用ELISA测定31例T1DM患者、33例T2DM患者和30名健康者(NC)血清visfatin水平，同时测定FPG、FIns、TG、TC、HDL-C、LDL-C及HbA₁c，计算WHR、BMI及胰岛β细胞功能指数（HOMA-β）。  结果  T1DM组血清visfatin水平较NC组和T2DM组减低，且T2DM组高于NC组[（96.4±52.0） vs （138.3±66.9） vs （205.7±82.2） pg/ml，P＜0.05]。T1DM组血清visfatin水平与BMI、WHR、FIns、HOMA-β呈正相关（r＝0.351、0.591、0.528、0.557，P均＜0.01）。多元逐步回归分析显示，WHR、HOMA-β是T1DM患者visfatin水平的独立相关因素。  结论 T1DM患者血清visfatin水平降低可能与WHR和HOMA-β降低有关。

【关键词】  糖尿病，1型；内脂素；胰岛β细胞功能

The changes and clinical significance of serum visfatin levels in patients with type 1 diabetes mellitus  XIANG Peng-yue, YAN Yan, GAO Lin, et al. Department of Endocrinology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

Corresponding author: GAO Lin, E-mail: lgzymc@sina.com

【Abstract】  Objective  to investigate the changes of  the serum visfatin levels in patients with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM )and normal control, and to explore the relationship between visfatin and glucose and lipid metabolism.  Methods  A total of 94 subjects were divided into 3 groups: 31 cases of T1DM (T1DM group), 33 T2DM (T2DM group), and 30 normal control (NC group).The serum visfatin levels were assayed with ELISA. FPG, 2 hPG, FIns, 2 hIns, TG, TC, HDL-C, LDL-C and HbA₁c were determined respectively. WHR, BMI, HOMA-IR and HOMA-β were calculated.  Results  (1) Compared with NC group and T2DM group, the serum visfatin levels of T1DM group significantly reduced [（96.4±52.0） vs （138.3±66.9） vs （205.7±82.2） pg/ml，P＜0.05]. However, the levels of visfatin in T2DM group  were significantly higher than in NC group (P＜0.01). (2) In T1DM group, serum visfatin levels were positively correlated with BMI, WHR, FIns and HOMA-β(r＝0.351, 0.591, 0.557 and 0.528，P＜0.01). (3) Multivariable logistic regression analysis showed that WHR and HOMA-β were independent risk factors of visfatin.  Conclusion  The lower serum visfatin levels in T1DM group may be associated with WHR and islet beta cell function.

【Key  words】  Diabetes mellitus, type 1; Visfatin; Islet beta cell function