来自:中国糖尿病杂志 编辑:王颖 佟俊旺 盛佳曦 魏剑芬 吴乃君等|点击数:|2016-04-25
【摘要】 目的 探讨血清瘦素、25羟维生素D[25(OH)D]水平与T2DM患者下肢血管病变(LLPAD)的关系。 方法 选取T2DM患者220例,根据下肢血管彩超检查结果分为LLPAD组100例和无下肢血管病变(Non-LLPAD)组120例,另选取健康体检者80名作为对照(NC)组。收集每组临床资料及生化指标,测定血清瘦素和25(OH)D水平。 结果 LLPAD组血清25(OH)D水平低于Non-LLPAD组[(23±13) vs (42±24) nmol/L,P<0.05],LLPAD组瘦素水平高于Non-LLPAD组[(7.24±0.46) vs (5.66±0.84) pg/ml,P<0.05]。Pearson相关分析发现,在各种人群中,瘦素与25(OH)D均呈负相关(P<0.01)。Logistic回归分析发现,年龄、SBP、HbA1c、LDL-C、瘦素、25(OH)D是糖尿病下肢病变的独立危险因素。 结论 高瘦素水平、低25(OH)D水平、高龄、高HbA1c、高SBP、高LDL-C与T2DM患者发生LLPAD密切相关。
【关键词】 糖尿病;下肢血管病变;瘦素;维生素D
Association analysis between serum leptin, 25-hydroxyvitamin D concentration and lower limb peripheral arterial disease in type 2 diabetic patients WANG Ying, TONG Jun-wang, SHENG Jia-xi, et al. Department of Endocrinology, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China
【Abstract】 Objective To explore the relationship between 25-hydroxyvitamin D [25(OH)D] and lower limb peripheral arterial disease(LLPAD). Methods A total of 220 type 2 diabetic patients and 80 healthy subjects were enrolled in this study. All the diabetic patients were divided into two groups according to their B ultra-sound results of lower limb peripheral artery: LLPAD group (n=110) and non-LLPAD group (n=120). Clinical data and routine biochemical indices were collected. Serum 25(OH)D and leptin were measured. Results 25(OH)D level was lower in LLPAD group than in Non-LLPAD group [(23±13) vs (42±24) nmol/L,P<0.05]. Leptin level was higher in LLPAD group than in Non-LLPAD group [(7.24±0.46) vs (5.66±0.84) pg/ml,P<0.05]. Multivariable logistic regression analysis revealed that age, SBP, HbA1c, LDL-C, leptin, and 25(OH)D were independent risk factors for LLPAD among diabetic patients. Pearson correlatim analysis showed that leptin was negatively associated with 25(OH)D in each group. Conclusion The development of LLPAD is siginificantly associated with increased levels of leptin, decreased level of 25(OH)D, old age, high level of HbA1c, SBP and LDL-C.
【Key words】 Diabetes mellitus,type2; Peripheral arterial disease; Leptin;Vitamin D
版权所有:《中国糖尿病杂志》社 主管单位:中华人民共和国教育部 主办单位:北京大学
地址:北京市西城区大红罗厂街1号 邮编:100034 电话(传真):010-88505683
中国糖尿病杂志社版权所 京ICP备11029051号-1 Powered by JiuduCMS 技术支持:九度创想