糖尿病与妊娠

　　[摘要] 目的 探讨妊娠期糖尿病(GDM)孕妇血清内脂素、瘦素(Leptin)水平变化的意义，并探讨两者与孕前BMI的相关性。方法 采用ELISA检测内脂素和Leptin的水平，并记录孕前体重、身高，计算BMI。结果 血清内脂素、胰岛素与HOMA-IR呈正相关(r=0.471、0.624,P<0.05),Leptin与孕前BMI、HOMA-IR呈正相关(r=0.492、0.605,P<0.05)。 结论 GDM患者存在IR，孕前BMI升高与妊娠期Leptin升高相关，内脂素、Leptin可影响GDM患者IR的程度。

　　[关键词]糖尿病，妊娠;内脂素;瘦素;体质指数

　　[Abstract] Objective To investigate the changes of serum visfatin and leptin levels inGDM and their relationships with progestation body mass index(BMI). MethodsThe levels of visfatin and leptin were measured by enzyme-linked immunosorbent assay (ELISA). The weight and height before pregnancy were recorded, and BMI was calculated as kg/m2. Results Serum visfatin was postively associated with fasting insulin (FINS) and HOMA-IR(r=0.471,0.624,P<0.05).Serum leptin was positively associated with progestation BMI and HOMA-IR(r=0.492,0.605,respectively,P<0.05). Conclusion Insulin resistance status exists in patients with GDM. The increase of BMI before pregnancy has relationship with the increase of serum leptin during pregnacy.The levels of leptin and visfatin may affect the extent of IR in patients with GDM.

　　[Key words] Diabetes, gestational;Visfatin; Leptin; Body mass index(BMI)