·文献综述·

　　【摘要】 自噬是在相关基因的调控下，自噬细胞溶酶体依赖性的降解细胞内受损的细胞器及大分子物质的过程。肥胖个体下丘脑、脂肪组织自噬水平改变，自噬参与了下丘脑控制进食及能量平衡调节，并且与脂肪细胞的分化、脂肪形成有关。自噬与肥胖发生的关系日益受到重视，为肥胖的发病机制研究及治疗提供了新的方向。

　　【关键词】 自噬;肥胖;下丘脑;脂肪形成

　　【Abstract】Autophagy is an intracellular degradation process by which the damaged organelles and macromolecules are lysosomal dependently degraded by auto-phagocyte under the control of autophagy-related genes. The autophagy level in hypothalamus and adipose tissue changes in obese individuals. Autophagy participates in the regulation of food intake and energy balance, and associates with adipocyte differentiation and adipogenesis. More and more attention has been paid to the relationship between autophagy and obesity which may guide the new research direction of pathogenesis study and therapy of obesity.

　　【Key words】 Autophagy; Obesity; Hypothalamus; Adipogenesis