·糖尿病临床研究·

　　【摘要】 目的 探讨新诊断T2DM患者血清尿酸(SUA)水平的影响因素。 方法 选取新诊断T2DM患者490例，根据SUA水平分为合并高尿酸血症(HUA)组(T2DM+HUA组)67例和单纯T2DM组(T2DM组)323例。测定临床及相关生化指标，分析SUA升高的影响因素。 结果 (1)新诊断T2DM患者高尿酸血症的患病率为13.67%(67/490)，男性高于女性[9.80%(48/490) vs 3.88%(19/490),P=0.012];(2)T2DM+HUA组BMI、WC、谷丙转氨酶(ALT)、谷草转氨酶(AST)、TG、C-P、胰岛素抵抗指数(HOMA-IR)均高于T2DM组，年龄、HbA1c、HDL-C、胰岛素敏感指数(HOMA-IS)低于T2DM组(P<0.05);(3)多元线性回归分析显示，年龄、女性及HDL-C为SUA的保护性因素，2 hC-P为SUA水平增高的危险因素。年龄是男性HUA的保护性因素，2 hC-P为SUA水平增高的危险因素。HDL-C和HOMA-IS为女性HUA的保护性因素，LDH和2 hC-P是女性HUA发生的危险因素。 结论 新诊断T2DM患者SUA水平受年龄、性别、肝功能、HDL-C及IS影响。

　　【关键词】 高尿酸血症;糖尿病，2型;新诊断;胰岛素敏感性

　　【Abstract】 Objective To explore the influencing factors for serum uric acid (SUA)levels in newly diagnosed type 2 diabetic patients(T2DM). Methods 490 cases of newly diagnosed T2DM were divided into groups: T2DM with high serum uric acid (T2DM+HUA , n=67) and T2DM without high uric acid group(T2DM, n=323) . The clinical and biochemical data were measured and the influencing factors of HUA were analyzed. Results (1)Prevalence rates of HUA in newly diagnosed T2DM were 13.67%(67/490), and the prevalence rates of HUA was higher in male than in female[9.80%(48/490)vs 3.88%(19/490), P=0.012]; (2) BMI, WC, alanine aminotransferase(ALT), aspartate transaminase(AST), TG, C-P, HOMA-IR were higher and age, HbA1c, HDL-C and HOMA-IS were lower in T2DM+HUA group than in T2DM group, (P<0.05); (3) Multivariable linear regression analyses showed that age, female and HDL-C were the protective factors for HUA, and independent risk factor for high SUA level was 2 hC-P. Age was the protective factor for male patients with HUA, and2 hC-P was risk factor for high SUA level. HDL-C and HOMA-IR were the protective factors for female, and LDH and 2 hC-P were risk factors for high SUA level. Conclusion Serum uric acid levels in newly diagnosed T2DM were affected by age, sex, liver function, HDL-C, and IS.

　　【Key words】Hyperuricemia(HUA); Diabetes mellitus, type 2; Newly diagnosed; Insulin sensitivity(IS)