【摘要】目的   探讨腹型肥胖患者成纤维细胞因子21(FGF-21)与肱踝脉搏波传导速度(baPWV)、肱动脉内皮依赖性舒张功能(FMD)的关系。 方法   在体检人群中选择腹型肥胖(腹型肥胖组)患者80例及健康人(NGT组)80名，测定FGF-21、baPWV、肱动脉FMD及胰岛素抵抗指数(In HOMA-IR)、HbA1c、血压及体脂含量(BFT)。 结果    腹型肥胖组baPWV、FGF-21、In HOMA-IR高于NGT组

(P<0.05或P<0.01)，肱动脉FMD低于NGT组(P<0.05)，FGF-21水平与BMI、BFT、WHR、TG、InHOMA—IR、Fins呈正相关(r＝

0.456、0.355、0.231、0.257、0.218、0.220，P<0.05或P<0.01)，Logistic回归分析发现，FGF-21、SBP、In HOMA-IR是发生动脉粥样硬化(AS)的危险因素(0R＝4.720、2.450、2.082，P<0.05)。 结论腹型肥胖患者肱动脉FMD下降，而baPwV升高，FGF-21可能对预测其早期AS有意义。
    【关键词】 腹型肥胖；成纤维细胞因子21；肱踝脉搏波传导速度；肱动脉内皮依赖性舒张功能；早期
动脉粥样硬化

    【Abstract】 Objective   To investigate the relationship between fibroblast growth factor-21(FGF-21) and brachial-ankle pulse wave velocity (baPWV)，brachial artery flow-mediated dilation(FMD)in patients with abdominal obesity． Methods   All the participants were divided into two groups：abdominal obesity group(n＝80) and NGT group (n＝80)．FGF-21，BaPWV，brachial artery FMD，ln HOMA-IR，HbA1c，blood pressure and body fat content (BFT) were measured in both groups． Results    BaPWV，FGF-21 and 1n HOMA-IR were significantly higher(P<0.05 or P<0.01)，but brachial artery FMD was significantly 10wer(P<0.05) in abdominal obesity group than in NGT group．FGF-21 level was positively correlated with BMI，BFT，WHR，TG，ln HOMA-IR and FIns(r＝0.456，0.355，0.231，0.257，0.218，0.220，P<0.05 or P<0.01)．Logistic regression analysis showed that FGF-21，SBP and In (HOMA—IR) were associated with AS (0R＝4.720，2.450，2.082，P<0.05)． Conclusion     Brachial artery FMD
decreases and baPWV increases in patients with abdominal obesity．FGF．21 may be helpful for early AS prediction．
   【Key words】 Abdominal obesity；Fibroblast growth factor-21(FGF-21)：Brachial-ankle pulse wavevelocity (baPWV)；Brachial artery flow-mediated dilation(FMD)；Early atherosclerosis