【摘要】 目的   探讨T2DM合并周围动脉疾病(PAD)患者血浆网膜素-1水平与炎症因子及相关代谢指标的关系。 方法   114例T2DM患者分为T2DM+PAD组和单纯T2DM组，各57例。另选正常对照者(NGT)68名。采用ELISA测定各组血浆网膜素-1水平、炎症指标及代谢参数，并对各变量行相关分析、多元逐步回归分析及Logistic回归分析。 结果   血浆网膜素一1水平在NGT组、T2DM、T2DM+PAD组逐渐降低(P<0.01)。血浆网膜素-1水平与TNF-a、IL-6、高敏C反应蛋白(hsC—RP)、FPG、HbA1c、TC呈负相关(r=-0.338、-0.225、-0.219、-0.263、-0.342、-0.235、-0.334，P<0.05或P<0.01)，与踝肱指数(ABI)及HDL-C呈正相关(r＝0.444、0.358，P<0.01)。多元逐步回归分析显示，TNF_n、HbAl C和TC是血浆网膜素一1独立相关因素Logistic回归分析结果显示，血浆网膜素-1、TNF．a、IL-6及HbA1c是T2DM患者发生PAD的影响因素。 结论  T2DM合并PAD与网膜素-1降低相关，网膜素一1表达可能会受到炎症因子的影响。
    【关键词】网膜素一1；周围动脉疾病；炎症因子；糖尿病，2型

    【Abstract】 Objective  To investigate the relationship between plasma omentin-1 level and inflammatory eytokines in T2DM patients with PAD． Methods    A total of 1 14 T2DM patients and 68healthy subjects were selected and divided into three groups：T2DM with PAD group (T2DM+PAD group. n=57)，T2DM without PAD group(T2DM group，n=57)and normal control group(NGT group，n=68)．Plasma omentin-1 level。inflammatory cytokines and metabolic parameters were measured in three groups，which were analyzed by correlation analysis，multiple stepwise regression analysis and logistic regression analysis． Results    Plasma omentin-1 levels of NGT group，T2DM group and T2DM+PAD group decreased in sequence (P<0.01)．Plasma omentin-1 level was negatively correlated with TNF-a，IL-6，hsC-RP，FPG，HbA1c and TC (r＝-0.338，-0.225，-0.219，-0.263，-0.342，-0.235，-0.334，PG<0.05 or P<0.01) and was positively correlated with ABI and HDL-C (r＝0.444，0.358，P<0.01)．Multiple stepwise regression analysis showed that TNF‘d、HbA1C and TC were independent related factors for plasma omentin-1．Logistic regression analysis showed that plasma omentin-1，TNF-α、IL-6 and HbA1C were influencing factors for T2DM in combination with PAD． Conclusion   Decrease of serum omentin-1 level is associated with PAD in T2DM patients． Expression of omentin-1 may be influenced by
inflammatory cytokines．
    【Key wards】  Omentin-1；Peripheral arterial disease(PAD)；Inflammation cytokines；Diabetes mellitus，