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血浆胰生血糖素样肽-1与2型糖尿病患者颈动脉内-中膜厚度的相关性研究

来自:中国糖尿病杂志  编辑:吴岚 张洁 赵力敏|点击数:|2016-02-24

     【摘要】 目的   探讨内源性胰升血糖素样肽-1(GLP-1)水平与T2DM患者颈动脉内一中膜厚度(CI-MT)的相关性。 方法   选取T2DM患者113例,根据GLP-1水平分为高值组(3.7 pmol/L<GLP-I<7.8 pmol/L)和低值组(0.7 pmol/L%GLP-1%3.6 pmol/L),检测两组CIMT及其他指标。 结果   高值组T2DM病程E(5.90±2.20)vs(6.40±2.50)年]、吸烟史E(8.10±4.30)vs(8.70±4.50)年]和CIMT[(0.71±0.17)vs(0.94±-0.24)mm]高于低值组(P<0.05)。校正性别、年龄、BMI、高血压、吸烟、LDL-C、log hsC-RP、log eGFR和log TG等变量后,多元回归分析显示,log GLP 1是CIMT的独立相关因素。
结论血浆GLP-1水平与CIMT呈正相关。
    【关键词】胰升血糖素样肽-1;糖尿病,2型;颈动脉内一中膜厚度    

    【Abstract】  Objective   To investigate the correlation between endogenous level of GLP-1 and carotid intima-media thickness (CIMT) in patients with type 2 diabetes (T2DM). Methods   A total of 113 T2DM patients were selected and divided into two groups by GLP-1 level:}1i曲GLP-1 group(3.7 pmol/L<GLP-I<7.8 pmol/L,n=57) and low GLP-1 group(0.7 pmol/L<GLP-1<3.6 pmol/L,n=56).All subjects underwent carotid ultrasonography and calculated CIMT values.Clinical and biochemical indices were measured in two groups. Results   Course of T2DM,years of smoking and CIMT were significantly higher in high GLP-1 group than in low GLP-1 group[(5.90±2.20)"vs(6.40±2.50) years,(8.10±
4.30) vs (8.70±4.50) years,(0.71±0.17) vs (0.94±0.24) mm,respectively;P<0.05].Multiple regression analysis showed that log hsC-RP was an independent related factor for CIMT after adjustment of such variables as gender,age,BMI,hypertension,smoking,LDL-C,log hsC-RP,log eGFR and log TG.Conclusion   Circulating GLP-1 level is positively correlated with CIMT.
    【Key words】  Glucagon-like peptide(GLP-1);Diabetes mellitus,type 2;Carotid intima-media thickness (CIMT)
 

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