【摘要】 目的   探讨骨代谢标志物骨钙素(OC)水平与老年T2DM动脉粥样硬化的关系。 方法   161例老年T2DM患者分为颈动脉

粥样硬化斑块组(CAS)73例、颈动脉内一中膜增厚组(CIMT增厚)52例及颈动脉内一中膜正常组(CIMT正常)34例。比较各组OC等水平。 结果    CAS组OC水平低于CI-MT增厚组及CIMT正常组(P<0.05)。相关分析结果显示，OC与HbA，C及高血压水平呈负相关

(r＝-0.454、-0.067，P＝0.006、0.036)。 结论    OS水平降低可能是老年T2DM患者CAS程度的危险因素。
    【关键词】 糖尿病，2型；骨钙素；动脉粥样硬化

    【Abstract】 Objective   To explore the relationship of osteocalcin(0C)level and the progress of atherosclerosis in elderly type 2 diabetic patients． Methods   A total of 161 elderly type 2 diabetic patients were divided into three groups according the carotid artery atherosclerosis：carotid atherosclerosis (CAS) group (n=73)，carotid intima—media thickness(CIMT)group(n=52) and intima normal group(n＝34)．OC levels were compared among the three groups． Results    The levels of OC in CAS group was 10wer than in CIMT and normal groups(P＜0.05)．The relationship between the OC and HbAl C levels was shown as negative(r＝-0.454，P＝0.006)，and that between the OC level and hypertension is alsonegative(r=-0.067，P=0.036)．In multivariate logistic regression analysis for the existence of atherosclerosis：the independent variable smoking wald test of regression coefficient no statistical significance(P=0.056)；Standardized regression coefficients shows that OC level was the most significant factor affecting the degree of the development of atherosclerosis，and the second and third most significant factors are respectively HbA1c and hypertension． Conclusion   Low level of osteocalcin in elderly type 2 diabetic patients is a risk factor for carotid atherosclerosis progress．
    【Key words】Diabetes mellitus，type 2；Osteocalcin(OC)；Atherosclerosis