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原发性痛风患者不同糖代谢状态下血清Nesfatin-1水平的变化

来自:中国糖尿病杂志  编辑:卢东晖 张帆 连晓芬等|点击数:|2016-02-25

    【摘要】 目的   观察原发性痛风性关节炎(GA)患者不同糖代谢状态下血清Nesfatin-1水平的变化。 方法   将研究对象分为GA组92例和正常(NC)组75名。GA组按血糖情况再分为GA-NGT亚组30例、GA-IGR亚组30例和新诊断GA-T2DM亚组32例。检测各组血糖、血脂、SUA、Fins、Nesfatin-1、HbA1c水平,稳态模型评估胰岛素抵抗指数(HOMA-IR)。 结果   GA组Nefastin-1水平高于NC组[(6.00±0.86)(4.79±1.28)ng/m1](P<0.05)。GA-T2DM、GA-IGR亚组Nesfatin-1水平均高于GA-NGT亚组[(6.75±

0.42)vs(5.88±0.67)VS(5.30+0.73)ng/m1](P<0.05)。多元逐步回归分析显示,Nesfatin-1与2 hPG、SUA、Fins呈正相关(P<0.05)。 结论GA患者Nesfatin-1水平升高,Nes-fatin-1可能参与了GA患者糖代谢调节。
    【关键词】糖代谢;痛风性关节炎;Nesfatin-1;糖尿病,2型

    【Abstract】 Objective   To investigate the change of serum Nesfatin-1 level in primary gouty arthritis(GA)patients with different glucose metabolism status. Methods   All the participants were divided into two groups:gouty arthritis group (GA group,n=92 )and normal control grou p(NC group,n=75).GA group was divided into three subgroups according to 75 g OGTT results:normal glucose tolerance subgroup (GA-NGT,n=30),impaired glucose regulation subgroup(GA-IGR,n=30) and newly diagnosed T2DM subgroup (GA-T2DM,n=32).Serum levels of glucose,lipid profile,SUA,Fins,Nesfatin-1,HbAl Cand HOMA-IR were measured in all subjects. Results Serum Nesfatin-1 level was significantly higher in GA group than in NC group[(6.00+0.86) vs (4.79-t-1.28)ng/m1]and also significantly higher inGA-

T2DM subgroup and GA-IGR subgroup than in GA-NGT subgrou p[(6.75±0.42)VS(5.88±0.67)vs(5.30+0.73)ng/mm](P<0.05).Multiple stepwise regression analysis showed that Nesfatin-1 level was positively correlated with 2 lapG,SUA and Fins (P<0.05). Conclusion   Nesfatin-1 may contribute to glucose metabolism regulation since it increased in GA patients.
   【Key words】  Glucose metabolism;Gouty arthritis(GA);Nesfatin-1;Diabetes mellitus,type 2

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