来自:中国糖尿病杂志 编辑:穆琚 庄晓明|点击数:|2016-02-24
【摘要】 目的 观察IGR患者血清血红素氧化酶-1(HO-1)、颈动脉内一中膜厚度(CIMT)及斑块形成情况,探讨HO-1在IGR伴或不伴动脉粥样硬化(AS)患者中的变化及影响因素。 方法 选取IGR者199例,接受颈动脉超声检测,根据病变性质分为颈动脉正常(CIMT≤0.9 mm)组124例和颈动脉斑块形成(CIMT≥1.5 mm,或有斑块形成)组75例,另设对照(NGT)组62名。ELISA检测血清HO-1水
平。 结果 颈动脉正常组和颈动脉斑块形成组HO-I水平高于NGT组,且颈动脉斑块形成组高于颈动脉正常组(P<0.05);Spearman相关分析显示,HO-1水平与SUA、TC、LDL-C、BMI呈正相关(r=0.126、0.204、0.187、0.207,P=0.042 0.001、
0.003、0.002);多元逐步回归分析显示,HOMA-IR、TC、CIMT是HO-1的危险因素( β=50.05、26.16、572.68,P=0.000、0.007、0.001);Logistic回归分析发现,HO-1为颈动脉粥样硬化的保护因素(OR=0.990,95%CI:0.981~0.999,P=0.000)。 结论 IGR患者检测血清HO-1水平可能有益于发现高AS患病风险者。
【关键词】 糖调节受损;血红素氧化酶一1;颈动脉粥样硬化
【Abstract】 Objective To investigate the change of H001 level and its influencing factors in IGR patients with/
without atherosclerosis. Methods A total of 199 IGR patients and 62 healthy subjects were envolved in this study.IGR patients were divided into two groups according tO CIMT detected by ultrasound:IGR patients with normal carotid artery group(CIMT≤0.9 mm,n=124),IGR patients with carotid plaque group (CIMT≥1.5 mm or have plaque,n=75).Serum level of HO-1 was tested by ELISA. Results Serum level of HO-1 was higher in IGR group than in NGT group and also higher in IGR patients with carotid plaque group than in IGR patients with normal carotid artery group(P<0.05)。Spearman correlation analysis showed that serum HO-1 level was positively correlated with SUA,TC,LDL-C and BMI(r=0.126,0.204,0.187,0.207,P=0.042,0.001,0.003,0.002).Multiple stepwise regression analysis showed that HOMA-IR,TC and CIMT were risk factors for serum H001 1evel (β=50.05,26.16,572.68,P=0.000,0.007,0.001).Logistic regression analysis showed that serum HO-1 was a protective factor for carotid atherosclerosis (OR=0.990,95%CI:0.981~0.999,P=0.000).Conclusion Serum HO-1 level test may be useful for identifying IGR patients with high risk of atherosclerosis.
【Key words】 Impaired glucose regulation(IGR);Heme oxygenase-1(HO-1);Carotid artery atherosclerosis(CIMT)
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