【摘要】 报道1例高龄T2DM合并葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏症患者。予安痛定后出现急性溶血，G-6-PD与6-磷酸葡萄糖脱氢酶(6-PGD)比值低于正常，提示G-6-PD缺乏症。降糖、抗感染、碱化尿液及输血等治疗有效。高血糖增加急性溶血的风险，在G-6-PD缺乏症高发区的糖尿病患者更应积极筛查G-6-PD活性。

【关键词】  糖尿病，2型；葡萄糖-6-磷酸脱氢酶；溶血

Elderly T2DM patients with glucose-6-phosphate dehydrogenase deficiency occurring acute hemolysis: A case report  LI Jian, WANG Heng, YU Lan. Department of Endocrinology, The First People`s Hospital of Zigong City, Zigong 643000, China

Corresponding auther: LI Jian, E-mail:lj8890111@163.com

【Summary】  An 88-year old woman with T2DM was reported occurring acute hemolysis after given antondin injection. G6PD/6PGD ratio was found less than normal which suggested the patient had glucose-6-phosphate dehydrogenase deficiency. Then the patient received such treatments as urine alkalization, insulin, antibiotics and blood transfusion, which was proved to be effective. So hyperglycemia may increase the risk of acute hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. It is significant to test glucose-6-phosphate dehydrogenase activity for T2DM patients in high incidence area of G6PD.

【Key words】  Diabetes mellitus,type 2; Glucose 6-phosphate dehydrogenase; Hemolysis