【摘要】临床研究发现叉头转录因子(FoxO)在糖尿病、卒中和衰老中发挥着不可忽视的作用.FoxO3属于叉头转录因子O亚群,广泛表达于机体组织,维持内环境稳态,调节多种病理生理过程,与寿命及年龄相关性疾病如肿瘤、糖尿病等密切相关.本文就FoxO3与糖尿病及并发症的关系做一综述.

    【关键词】叉头转录因子；糖尿病；糖尿病并发症

Research process inthe relationship between forkhead transcription factorsand diabetes and its complications CHEN juan, LI Wei,SUN Zi-Lin. Medical School of Southeast University,Nanjing 21009 Corresponding author: SUN Zi-Lin, Email: sunzilin1963@126.cpm

【Summary】Clinical studies havefound that forkhead that forkhead transcription factors (FoxO) play animportant role in diabetes mellitus, strokeand aging. FoxO3, a member of  FoxO  O subgroup, widely expressed in various tissues and involved in maintaining homeostasisand regulating a variety of pathophysiological processes. FoxO3 is also significantly associated with lifespan and age-related diseases such as cancer and diabetes mellitus.In this article we will make a brief review on the relationship between FoxO3 and diabetes and its complications.      

【Key words】Forkhead transcription factors(FoxO); Diabetes mellitus; Diabetic complications