·糖尿病临床研究·

　　【摘要】 目的 探讨DKA患者水盐代谢异常与病情的相关性及治疗中的注意事项。 方法 将262例受试者根据血钠水平分为高钠(G1)组43例(Na>145 mmol/L，)、正常血钠(G2)组109例(135 mmol/L≤Na≤145 mmol/L)、轻度低钠(G3)组86例(125 mmol/L≤Na≤13 5mmol/L)及显著低钠(G4)组24例(Na<125 mmol/L)，评估不同血钠水平下的临床及实验室资料。 结果 血钠与意识障碍、BUN/Cr、有效渗透压、HCO3―存在相关性(r分别为0.341、0.123、0.853、0.196，P<0.05或P<0.01)。 结论 在DKA患者中常见水盐代谢异常，应注意监测及时纠正。

　　【关键词】 糖尿病酮症酸中毒;水盐代谢

Correlation between abnormal serum sodium level and clinical disturbance in patients with diabetic ketoacidosis ZHU Cong，ZHANG Mu-xun，YUAN Gang，et al. Department of Endocrinology, Tongji hospital ,Tongji Medical College, Huazhong University of Science and Technology,Wuhan40030,China

Corresponding author: ZHANG Mu-xun,E-mail:zmx1220@sina.com

　　【Abstract】 Objective To investigate the correlation between serum sodium level and clinical disturbance in patients with diabetic ketoacidosis. Methods 262 patients with diabetic ketoacidosis were divided into 4 groups according to Na levels :high sodium(G1) group(Na>145 mmol/L，n=43),normal sodium(G2) group(135 mmol/L≤Na≤145 mmol/L,n=109),mild deficiency sodium(G3) group(125 mmol/L≤Na≤13 5mmol/L,n=86) and severe deficiency sodium(G4) group. Clinical and laboratory data were evaluated among four groups. Results The Na level was significant correlated with disturbance of consciousness ，BUN/Cr, effective osmotic pressure, HCO3-(r =0.341, 0.123, 0.853, 0.196, P<0.05 or P<0.01﹚. Conclusion Different abnormality of serum sodium level is associated with different clinical disturbance in patients with diabetic ketoacidosis in DKA parients.

　　【key words】 Diabetes ketoacidosis;Serum sodium