·文献综述·

　　【摘要】钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂通过抑制SGLT2转运蛋白促进肾脏排出葡萄糖以改善血糖水平。与其他口服降糖药或胰岛素联用可增加降糖效果。还可通过尿液排出过多卡路里以减轻体重，可为糖尿病患者提供更好的治疗效果。随着病情进展，糖尿病患者肾小球滤过功能降低，SGLT2抑制剂可能有肾脏保护作用。

　　【关键词】糖尿病;钠-葡萄糖协同转运蛋白2;钠-葡萄糖协同转运蛋白2抑制剂

Latest research progress on treatment with sodium-glucose cotransporter 2 inhibitors in diabetes mellitus LIU Kai,SONG Hai-yan.Department of Endocrinology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China

Correspond author：SONG Hai-yan，Email:songhy6605@126.com

　　【Summary】 The mechanism of action of Sodium-glucose cotransporter 2 (SGLT2) inhibitors is that SGLT2 inhibitors can modulate renal glucose reabsorption and plasma glucose level.They can combinedly be used with other oral antidiabetic drugs or insulin with better hypoglycemic effects. Weight loss owing to urinary calorie leakage and the negative energy balance offer a valuable clinical benefit. Through reducing glomerular filtration rate, SGLT2 inhibitors may decrease the progression of the disease and play a renal protective role.

　　【Key words】Diabetes mellitus;Sodium-glucose cotransporter 2 (SGLT2);Sodium-glucose cotransporter 2 inhibitors