·糖尿病临床研究·

　　【摘要】 目的　对新诊断的T2DM患者早期给予胰岛素泵强化(CSII)治疗,观察对血糖长期良好控制及胰岛β细胞功能恢复的研究。方法　对新诊断T2DM 患者给予CSII治疗2~3周，血糖正常后给予单纯饮食控制和运动疗法，不使用任何降糖药物，观察3、6个月,1、2及3年血糖控制及胰岛β细胞功能恢复情况。结果　CSII治疗后较FPG、2 hPG和HbA1c均下降(P<0.01),胰岛素、C-P升高(P<0.01)。随访结果显示,血糖达标后,单纯饮食控制和运动疗法干,且不使用任何降糖药物，血糖保持正常患者比率为:3个月72%，6个月66.7%，1年49.9%，2年45.2%，3年32.1%。 结论　对新诊断T2DM患者早期给予CSII，能快速解除高血糖毒性，可使血糖迅速达标，从而改善IS,有利于保护胰岛β细胞功能，或有利于胰岛β细胞功能得到改善。

　　【关键词】 胰岛素泵;糖尿病, 2型;血糖;新诊断;胰岛素;C-肽

The intensive therapy of insulin pump for type 2 diabetic patients the study of long-term glycemic control and islet beta-cell function improvement in diabetes mellitus  CHI Zhi-bo, YAN Ping, ZHAO Hong-xia. Department of Endocrinology,Penglai People's Hospital, Penglai 265600,China

　　【Abstract】 Objective The early intensive therapy of insulin pump was used applied to the primordiacprimordial patients with type 2 diabetes. To further observe the affect effect on long-term glycemic control and the function rehabilitation of islet beta-cell. Methods We give the 316 patients accepted insulin pump therapy for 2-3 weeks, who were newly diagnosed type 2 diabetic patients with fasting blood glucose ≥ 11.1 mmol/ L. After blood glucose became normalthat, they were treated with the method of normal blood sugar diet and exercise alone without any hypoglycemic drugs. Then we observed the glycemic control and islet β cell function recovery after 3 months, 6 months, 1 year, 2 years and 3 years. Results Fasting blood glucose, postprandial blood glucose and HbA1c There was an dramatically decreased in fasting blood glucose, postprandial blood glucose and HbA1c after the insulin pump treatment (P<0.01). Compared with the result before the treatment, p<0.01.Besides, After the treatment, insulin and, C-peptide were significantly increased (P<0.01). Compared with the result before the treatment, p<0.01. After the blood glucose met the normal level, the patients accepted only diet control and exercise only and without rather than any antidiabetic drugs were offered. The follow-up survey on those patients shows that 72% can have normal blood glucose after 3 months after the treatment, 72% can have a normal blood glucose ratio, 66.7% after 6 months, 49.9% after a year, 45.2% after 2 years and 32.1% after 3 years. Conclusions Treatment on newly diagnosed type 2 diabetic patients by early insulin pump therapy can help quickly relieve high blood glucosesugar toxicity, make blood glucosesugar rapidly return to normal. Therefore, the insulin sensitivity is significantly improved and islet β cell function is protected. Furthermore, the blood glucose is well controlled and pancreatic β cell function is improved.

　　【Key words】 Insulin Pump; Diabetes mullitus, type 2;Blood glucose;New diagnose;Insulin;C-peptide