·糖尿病胰岛素治疗·

　【摘要】 目的 探讨老年超重、肥胖T2DM患者在口服降糖药基础上加用每日一次地特胰岛素(Det)治疗的临床疗效及安全性。方法 93例老年超重、肥胖T2DM患者随机分为A、B组。A组口服二甲双胍、阿卡波糖;B组口服药+地特胰岛素，疗程24周。观察两组治疗前后FPG、2 hPG、BMI、HbA1c及低血糖发生率等情况。 结果 24周后，B组FPG、2 hPG、HbA1c、BMI较基线及A组降低(P<0.05)，且无夜间低血糖发生。结论 Det 联合低剂量二甲双胍、阿卡波糖可有效控制老年超重、肥胖T2DM血糖，优于单纯口服给药，并能控制体重，且无夜间低血糖发生。

　　【关键词】 地特胰岛素;超重;肥胖;糖尿病，2型

Clinical therapeutic effects and safety of insulin detemir combination with low dosage of metformin and acarbose on elderly overweight and obese type 2 diabetic patients YANG Dong-ming , YAN Ping. HE Hua-wei,et al. Department of Geriatrics, The Southern Branch of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 201400,China

Corresponding author:HAN Ying,E-mail:xjhy0519@163.com

　　【Abstract】 objective To observe the clinical efficacy and safety of once a day daily insulin detemir combined with oral hypoglycemic agents in elderly type 2 diabetes with overweight and obese patients. overweight and obese patients with type 2 diabetes. Methods 93 cases of elderly overweight and obese patients with type 2 diabetes were randomly divided into 2 groups, .group Group A was treated with oral metformin and acarbose , while patients in group B was added were given insulin detemir on the basis of group A , except metformin and acarbose. both of them were observed the indicators of Indicators,such as FPG, 2 HPG 2 hPG, BMI, HbA1c and hypoglycemia incidence were recorded before and after treatment for 24 weeks. Results After During the 24 weeks following-up,the indicators of FPG, 2 hPG，HbA1c，and BMI in group B were decreased significantly comparing when compared with self baseline(P< 0.05), FPG、2 hPG、HbA1c and BMI and those in group B were significantly lower than group A (p P< 0.05), no cases of nocturnal hypoglycemia occurred at night. Conclusion s Combination of insulin detemir with low dose metformin and acarbose could control the blood sugar effectively in elderly overweight and obese patients with type 2 diabetes, which was better than that of pure oral dosing, which also and could well control weight and no prevent the incidence of nocturnal hypoglycemia occurr during night.

　　【key words】 Insulin detemir;Overweight;Obesity;Diabetes mellitus, type2