·药物研究动态·

　　【摘要】低血糖，尤其是重度和夜间低血糖不仅增加不良事件的发生风险，而且妨碍降糖治疗。相比于预混人胰岛素30R，双时相门冬胰岛素30的药代动力学特征更好的模拟了生理胰岛素分泌模式。多项临床试验以及荟萃分析均证实，双时相门冬胰岛素30在有效控制血糖的同时，还能够显著降低重度和夜间低血糖的发生风险，从而减小低血糖给糖尿病患者带来的巨大危害，实现安全控糖。

　　【关键词】双时相门冬胰岛素30;糖尿病;低血糖;胰岛素类似物

Superiority of biphasic insulin aspart 30 in reducing the risk of hypoglyceamia   SU Ben-li. Department of Endocrinology, Second Affiliated Hospital of Dalian Medical University, Dalian 150086, China

　　【Abstract】Hypoglyceamia, especially severe hypoglyceamia and nocturnal hypoglyceamia, increases the risk of multiple diseases, and disturbs the antihyperglyceamic pharmacotherapies. Compared with biphasic human insulin 30R, the pharmacokinetics of biphasic insulin aspart 30 better mimics the physiological secretion of human insulin. Various clinical tirals and meta analysis have demonstrated that biphasic insulin aspart effectively controlled blood glucose, and also significantly decreased the risk of severe and nocturnal hypoglyceamia, therefore reducing the harm of hypoglyceamia in people with diabetes. In conclusion, biphasic insulin aspart 30 helps to achieve the goal of blood glucose safely and effectively.

　　【Key words】Biphasic insulin aspart 30;Diabetes;Hypoglyceamia;Insulin analogue