·糖尿病神经病变·

　　【摘要】目的 探讨血脂异常与糖尿病周围神经病变(DPN)是否存在相关性。 方法 将201例患者根据是否合并血脂异常分为单纯T2DM组68例、T2DM合并血脂异常组66例、单纯血脂异常组32例、健康对照(NC)组35名，采用感觉神经定量检测仪测定各组正中、腓肠神经于2000、250、5 Hz的电流感觉阈值(CPT)，检测相关生化指标。 结果 T2DM合并血脂异常组较T2DM组CPT升高(P<0.05)，5 Hz时CPT升高最显著(P<0.01)。单纯T2DM组和单纯血脂异常组双侧正中、腓肠神经比较差异无统计学意义。单纯血脂异常组双侧正中、腓肠神经CPT较NC组升高(P<0.05或 P<0.01)。 结论 血脂异常与高糖毒性是DPN的两个等位危险因素，高糖合并血脂异常可加快DPN发生发展。

　　【关键词】糖尿病周围神经病变;血脂异常;电流感觉阈值

A preliminary observation on clinical significance of quantitative sensory testing instrument for diabetic patients GAO Qing,LI Quan-min,TANG Feng-yan,et al. Department of Endocrinology, The Second Artillery General Hospital Peopleˊs Liberation Army, Beijing 100088, China

Corresponding author：LI Quan-min，E-mail：liqm0806@163.com

　　【Abstract】 Objective To explore the relationship between dyslipidemia and diabetic peripheral neuropathy (DPN). Methods 201 patients were divided into T2DM group by 68 patients, T2DM with dyslipidemia group by 66 patients, dyslipidemia group by 32 patients and normal control (NC) group by 35 subjects. Using the Neurometer, CPT testing at 2000, 250 and 5 Hz was performed on median and peroneal nerves. Biochemistry of all of the above four groups were tested. Results Compared with T2DM group,the CPT in T2DM with dyslipidemia group was significantly higher(P<0.05), especially at low frequency(5 Hz, P<0.01). There was no CPT difference between T2DM group and dyslipidemia group. Compared with NC group, the CPT in dyslipidemia group was higher(P<0.05 or P<0.01). Conclusion Hyperglycemia and dyslipidemia are two important risk factors lead to DPN. Hyperglycemia combined dyslipidemia can accelerate the happening and development of DPN.

　　【Key words】Diabetic peripheral neuropathy (DPN);Dyslipidemia;Current perception threshold (CPT)