·糖尿病神经病变·

　　【摘要】 目的 探讨单唾液酸神经节苷脂钠(GM1)联合α-硫辛酸治疗糖尿病周围神经病变(DPN)的疗效及安全性。 方法 将DPN患者80例分为治疗组40例和对照组40例。在控制血糖的基础上，治疗组予静脉滴注GM1 40 mg和α-硫辛酸600 mg，对照组予静脉滴注α-硫辛酸600 mg，均1次/d，疗程2周。观察治疗后症状改善情况，测定治疗前后正中、腓总神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)。 结果 2周后，治疗组总有效率92.5%(37/40)，对照组总有效率72.5%(29/40)，治疗组疗效较对照组改善显著(P<0.05)。两组MNCV、SNCV均较治疗前提高(P<0.05)，治疗组提高更显著(P<0.05)。 结论 GM1联合α-硫辛酸治疗DPN疗效显著。

　　【关键词】 糖尿病周围神经病变;单唾液酸神经节苷脂钠;α-硫辛酸

The therapeutic effect of monosialotetrahexosylganglioside combined with α-lipoic acid on diabetic peripheral neuropathy ZHANG Fan, ZHANG Li, HE Jun. Department of Endocrinology, The Third Peopleˊs Hospital of Changzhou, Changzhou 213001, China

　　【Abstract】Objective To evaluate the therapeutic effect of monosialotetrahexosyl-ganglioside (GM1) combined with α-lipoic acid on diabetic peripheral neuropathy (DPN). Methods 80 patients with DPN were divided into the treatment group and the control group，additional to the regular treatment to control blood glucose, 40 patients in the treatment group treated with GM1 40 mg and α-lipoic acid 600 mg daily through intravenous drip for two weeks, 40 patients in the control group treated with α-lipoic acid 600 mg daily through intravenous drip for two weeks.All patients were examined on the improvement of symptoms，motor and sensory nerve conduction velocity of the median nerve and nervus peroneus communis before and after the treatment.Results After treatment for two weeks，the overall effect rate in the treatment group was 92.5%(37/40), which was significantly higher than that in the control group 72.5%(29/40) (P<0.05).In the treatment group and the control group，the motor nerve conduction velocity and the sensory nerve conduction velocity after treatment were all significantly higher than that before treatment (P

　　【Key words】Diabetic peripheral neuropathy (DPN);Monosialotetrahexosyl-ganglioside (GM1);α-lipoic acid