2型糖尿病患者胰岛β细胞功能衰竭与脂联素和抵抗素的临床相关研究
来自:中国糖尿病杂志 编辑:周广朋 张景岚 张敏 周青 贾晓利 杨明|点击数:|2014-02-13
【摘要】目的 探讨T2DM患者胰岛β细胞功能衰竭所致血清APN和抵抗素的变化特点及临床意义。 方法
选取T2DM病程<6个月者21例,6个月2年者18例及健康对照(NC)者21名。测量身高、体重、血压和WC,检测真胰岛素(TI)、胰岛素原(PI)、APN、抵抗素、FPG、FIns、TG、TC、HDL-C和LDL-C,计算胰岛素分泌指数(HOMA-β)。
结果
随着T2DM病程进展,胰岛β细胞功能进行性下降,TI分泌逐渐减少(P<0.05)。T2DM病程较长组PI高于病程较短及NC组(P<0.05)。T2DM各组APN、抵抗素、TC、LDL-C和TG与NC组比较差异有统计学意义(P<0.05)。
结论 随着T2DM病程进展,胰岛β细胞功能逐渐衰竭,且伴随血浆APN和抵抗素水平改变,这可能是导致T2DM发病原因之一。
【关键词】糖尿病,2型;胰岛β细胞功能衰竭;脂联素;抵抗素
Relationship of serum adiponectin and resistin with pancreatic β cell
dysfunction in type 2 diabetes ZHOU Guang-Peng, ZHANG Jing-Lan,ZHANG min,et al.
No. 1 Department of Internal Medicine, East Department of Sichuan Provincial
Peopleˊs Hospital, Chengdu 610106, China
Corresponding author:CHEN Shu, E-mail:chenshu_98@yahoo.com
【Abstract】Objective To investigate the relationship of serum adiponectin
and resistin with pancreatic β cell dysfunction and their clinical significance
in T2DM patients. Methods T2DM patients with coursetwo years in 18 cases and normal
control (NC) in 21 cases were selected. Height, weight, blood pressure, WC,
serum concentration of true insulin (TI), proinsulin (PI), adiponectin,
resistin, FPG, FIns, TG, TC, HDL-C, LDL-C were detected and HOMA-β was
calculated. Results The HOMA-βwhich reflects the secretory function of
pancreatic β cell declined significantly with the progress of T2DM(P<0.05).
TI and PI were significantly higher in long course T2DM group than in short
course T2DM and NC group (P<0.05). The serum resistin,TG, TC and LDL-C were
significantly increased in each T2DM group than in NC group (P<0.05).
Conclusion Along with the progress of T2DM and decreased secretory function of
pancreatic β cell, serum adiponectin declines , and serum resistin increases
gradually and significantly which may correlate with T2DM development.
【Key words】Diabetes mellitus,type 2;Pancreatic β cell
dysfunction;Adiponectin;Resistin