【摘要】  目的  探讨T2DM患者血清对氧磷酶3(pon3)水平与血糖、血脂、IR等代谢因素及T2DM早期颈动脉粥样硬化(CAS)的关系。方法 选择新诊断T2DM患者108例，根据有无CAS分为合并CAS组(A，53例)，不合并颈动脉斑块组(B，55例)。另选择健康体检者为对照(C，54例)组;采用ELISA方法测定空腹血清pon3水平，检测血脂、同型半胱氨酸(Hcy)、纤维蛋白原(Fib)、HbA1c、FPG、hsC-RP、超氧化物歧化酶(SOD)等指标,采用稳态模式评估胰岛素抵抗指数(HOMA-IR)。结果 3组血清pon3水平依次为: C组(2.24±0.44)

　　【关键词】 对氧磷酶3;糖尿病,2型;颈动脉粥样硬化

Association of serum pon3 with carotid atherosclerosis in newly diagnosed T2DM patients LIU Yun-tao, Jian Lei, Li Jian-Wei, et al. Department of Endocrinology, Renhe Hospital of China Three Gorges University, Yichang 443000, China

　　【Abstract】 Objective To explore the association of serum paraoxonase-3 (pon3) with serum glucose, lipid, insulin resistance, and the carotid atherosclerosis (CAS) in the newly diagnosed T2DM patients. Method The 108 patients with newly diagnosed T2DM were divided into T2DM with CAS group (Group A, n=53), and T2DM without CAS group (Group B, n=55). The 54 healthy people with normal glucose tolerance were selected as the controls (Group C). Serum pon3 was measured with the ELISA method. FPG, 2 hPG, FIns, HbA1c, hsC-RP, and lipid profiles, homocysteine (Hcy), fibrinogen (Fib), and superoxide dismutase (SOD) were measured as well. BMI and waist-to-hip ratio (WHR) were recorded and insulin sensitivity was assessed by HOMA-IR. Results The serum pon3 levels of the three groups were in an order of Group C (2.24±0.44) < Group B (2.72±0.51)

　　【Key words】 Paraoxonase-3 (pon3); Diabetes mellitus, type 2; Carotid atherosclerosis (CAS)