来自:中国糖尿病杂志 编辑: 王兰英 彭建霞 杨慧 王瑞玲 刘树艳|点击数:|2014-11-24
·糖尿病胰岛素治疗·
【摘要】 目的 比较胰岛素泵持续皮下注射(CSII)与胰岛素多次皮下注射(MSII)方案治疗儿童T1DM的疗效及安全性。 方法 T1DM患儿72例随机分为CSII组32例与MSII组40例,治疗3个月。比较治疗前后FPG、2 hPG、HbA1c、24 h血糖波动情况及低血糖事件发生率。 结果 (1)治疗后,两组FPG和HbA1c均较治疗前降低降低(P<0.05),但两组间比较差异无统计学意义(P>0.05);(2)CSII组24 h内平均血糖波动幅度(MAGE)、全天血糖值标准差(SDBG)、日间血糖平均绝对差(MODD)均低于MSII组[MAGE: (1.9±0.5) vs (2.2±0.4) mmol/L;SDBG:(2.1±0.3) vs (2.4±0.4);MODD:(3.3±1.4) vs (4.1±1.5),P<0.05];(3)CSII组低血糖发生率低于MSII组,但两组均无严重低血糖事件。 结论 CSII治疗血糖波动较大的T1DM患儿疗效和安全性均优于MSII。
【关键词】 糖尿病,1型;儿童;胰岛素持续皮下注射
【Abstract】 Objective To compare efficacy and safety of continue subcutaneous insulin pumb injection on tpye 1 diabetes mellitus children. Methods 72 cases with T1DM children were randomized into CSII (n=32)and MSII (n=40) group and treatment for three months. FPG, HbA1c, 24 h blood glucose fluctuation and hypoglycemic events were compared between before and after treatment. Results (1)After treatment, the levels of FPG and HbA1c were significantly lower than before treatment in two groups (P<0.05), but there was no statistically significant differences between the two groups (P>0.05);(2)The MAGE、SDBG、MODD indexes in 24 h were lower in CSII group in MSII group [MAGE: (1.9±0.5) vs (2.2±0.4) mmol/L;SDBG:(2.1±0.3) vs (2.4±0.4);MODD:(3.3±1.4) vs (4.1±1.5),P<0.05];(3)The incidence of hypoglycemia was lower in CSII group than in MSII group, both two groups had no severe hypoglycemia events. Conclusion Efficacy and safety of CSII is better than MSII on type 1 diabetes mellitus children with blood sugar volatility bigger.
【Key word】 Diabetes mellitus,type 1;Children;Insulin pump injection subcutaneous injection
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