【摘要】 目的 观察新诊断T2DM患者短期胰岛素强化降糖治疗后影响血糖长期缓解的因素。 方法 选取新诊断T2DM患者32例胰岛素泵治疗2周，测定治疗前后OGTT 0.5 h、1 h、2 hPG及Ins，计算胰岛β细胞功能(HOMA-β)、胰岛素抵抗指数(HOMA-IR)和第一时相胰岛素分泌(ΔI30/ΔG30)。观察3年后血糖缓解情况，分析影响因素。 结果 胰岛素泵强化治疗后，FPG、0.5 hPG、2 hPG、HOMA-IR均较治疗前下降，HOMA-β和ΔI30/ΔG30升高(P<0.01)。3年后血糖缓解率为28.1%(9/32)。Logistic回归分析显示，强化治疗后有氧运动是血糖长期缓解的重要因素(OR=24，P<0.05)。 结论 新诊断T2DM患者短期胰岛素泵强化治疗可长期缓解血糖，有氧运动是血糖长期缓解的重要因素。

　　【关键词】 糖尿病，2型;持续胰岛素皮下输注;有氧运动

　　【Abstract】 Objective To observe the effect of long-term glycemic control of insulin pump for therapy on newly diagnosed type 2 diabetic patients and its influencing factors. Methods 32 patients with newly diagnosed type 2 diabetes were treated with continuous subcutaneous insulin infusion (CSII) therapy for 2 weeks. OGTT 0.5 h、1 h、2 hPG and Ins were measured, and HOMA-β, HOMA-IR, and early-stage insulin secretion index(ΔI30/ΔG30) were calculated before and after treatment. Patients who maintained glycemic control for 3 years were defined as remission while those who failed to maintain glycemic control as hyperglycemia relapse. Results After CSII, the level of FPG、0.5 hPG、2 hPG、HOMA-IR was lower after treatment than before treatment, but HOMA-β and ΔI30/ΔG30 was higher(P<0.01). The remission rate of blood glucose was 28.1%(9/32). Logistic regression analyses showed that aerobic exercise after CSII was independent predictor of long term euglycemia remission (OR=24, P<0.05). Conclusion Newly diagnosed T2DM patients with short-term insulin pump intensive therapy can relieve blood glucose for a long time, aerobic exercise after CSII is a convenient and significant predictor for long term euglycemia remission.

　　【Key words】 Diabetes mellitus， type 2;Continuous subcutaneous insulin infusion;Aerobic exercise