药物研究动态

　　　【摘要】肥胖不仅是T2DM的发病危险因素之一，且在已患有T2DM的患者中，超重或肥胖可明显增加其并发症的发生风险。因此，有效的体重管理不仅可改善血糖控制，同时有可能减少大血管和微血管并发症的发生风险。基于肠促胰素治疗的利拉鲁肽，在降低血糖的同时有效控制体重，为超重或肥胖T2DM患者提供了更好的选择。本文就T2DM患者体重管理的重要性及利拉鲁肽在体重管理方面的优势进行综述。

　　【关键词】糖尿病,2型;体重管理;利拉鲁肽

　　　【Summary】 Obesity is not only the risk factor of type 2 diabetes mellitus (T2DM), but also significantly increase the incidence of complications in T2DM patients. Therefore, Effective weight management can improve blood glucose control, at the same time it may reduce the risks of macrovascular and microvascular complications. Liraglutide, which is the incretin-based therapy, reduces blood glucose and body weight appropriately. Thus, liraglutide will be a better choice for T2DM with overweight or obesity. Here we systematically review the importance of weight management in T2DM patients, and the advantages of liraglutide on weight management.

　　【Key words】 Diabetes mellitus，type 2; Weight management; Liraglutide