【提要】T2DM患者常合并多重心血管危险因素，如血脂异常、高血压、治疗过程中常伴发的低血糖、体重增加等。因此，T2DM患者是心血管疾病的高危人群。为降低T2DM的心血管风险，应控制血糖、血压、血脂、体重等指标。胰升血糖素样肽-1(GLP-1)受体激动剂在动物、细胞研究及临床试验中均显示具有心血管保护作用，可用于T2DM合并心血管疾病的管理。

　　【关键词】糖尿病，2型;心血管疾病;胰升血糖素样肽-1;胰升血糖素样肽-1受体激动剂

　　【Summary】Type 2 diabetes is often combined with multiple risk factors for cardiovascular disease, such as dyslipidaemia, hypertension, hypoglycaemia and weight gain induced by anti diabetic drugs.Patients with type 2 diabetes are at high risk for cardiovascular diseases. To minimize the risk for cardiovascular disease, comprehensive management on hyperglycaemia, hypertension,dyslipidaemia and overweight /obesity is essential. Recent studies had revealed the beneficial effects of GLP-1 on cardiovascular system.

　　【Key words】Diabetes mellitus,type 2;Cardiovascular diseases;Glucagon-likepeptide-1(GLP-1);Glucagon-likepeptide-1(GLP-1)receptor agonists