文献综述

　　【摘要】IR是T2DM、非酒精性脂肪性肝病等代谢性疾病的共同发病基础，肝脏IR对糖脂代谢异常和脂肪肝的发生发展起介导作用。内质网应激(ERS)与肝脏IR的发生发展密切相关。本文对ERS和肝脏IR关系的相关研究进展作一综述。

　　【关键词】内质网应激;胰岛素抵抗;肝脏

　　【Summary】 IR is the common pathogenesis of metabolic diseases, including T2DM, nonalcoholic fatty liver disease, and so on. Hepatic IR plays a central role in mediating the development of glucose and lipid metabolic disorder. Endoplasmic reticulum stress (ERS) is closely associated with the development of hepatic IR. The present review summarized the related research findings on the relationship between ERS and IR.

　　【Key words】Endoplasmic reticulum stress (ERS);Insulin resistance (IR);Hepar