·述评·

　　【摘要】 糖尿病周围神经病变(DPN)是糖尿病主要慢性并发症之一，严重影响患者的生活质量。早期诊断及治疗是降低DPN、提高患者生活质量的关键。目前使用的诊断方法中，问卷调查法简单易行，非侵入性检查法研究与使用日益广泛，有创检查方法不断完善，而对生物标志物的检测正在探索中。对DPN的治疗除了控制血糖，尚无其他有效对因治疗方法，新近研究主要集中在镇痛药物和抗氧化应激治疗领域，其他药物及非药物性治疗尚缺乏大样本研究。基因治疗及干细胞治疗正在探索中。今后的研究方向可能重在于，加深发病机制的认识以促进新药研发，以及药物合理联合应用优化治疗策略。

　　【关键词】 糖尿病周围神经病变;诊断 ;治疗

Progress in the diagnosis and treatment of diabetic peripheral neuropathy LI Ying, LI Gang, FENG Bo. Department of Endocrinology, East Hospital Affiliated to School of Medicine, Tongji University, Shanghai 200120, China

Corresponding Author: FENG Bo, E-mail: fengbo@medmail.com.cn

　　【Summary】Diabetic peripheral neuropathy (DPN) is one of the most severe diabetic chronic complications. Early diagnosis and treatment play a key role in reducing the degree of disability and improving the life quality of the patients. Among the currently used diagnostic methods, questionnaire method is simple and non-invasive, non-invasive inspection methods are extensively studied and used, invasive inspection methods are improved continuously, and the detection of biomarkers is being explored as well. At present, there are no effective etiological treatment, except the glycemic control, in the treatment of DPN. Current researches mainly focus on the development of analgesic drugs and antioxidants. Gene and stem cell therapies are being explored. The direction of studies from now on is to deepen the comprehension of pathogenesis of this disease to develop the new drugs and optimize the treatment strategy in combination use of drugs.

　　【Key words】Diabetic peripheral neuropathy (DPN); Diagnosis; Treatment