·糖尿病临床研究·

　　【摘要】 目的 探讨血清生长停滞特异性基因产物6(GAS6)的水平与T2DM和肥胖的相关性及临床意义。 方法 新诊断T2DM患者(T2DM组) 46例和NGT者(NGT组) 42名按BMI ＜18.5 kg/m2＜24.9 kg/m2或≥25 kg/m2 又各自分为正常体重和超重/肥胖亚组。采用ELISA法测定空腹血清GAS6水平。结果T2DM组血清GAS6浓度低NGT[(10.63±1.95)vs(14.27±3.82)ng/ml](P<0.01)。偏相关分析显示，血清GAS6与BMI、WC、FPG、HbA1c、C-RP、TNF-α、6呈负相关(r分别为-0.235、-0.266、-0.362、-0.427、-0.268、-0.442、-0.38，P<0.05或P<0.01)，与HDL-C呈正相关(r=0.235，P<0.05)。多元逐步回归分析显示，BMI 、HbA1c、TNF-α(β分别为-0.19、-0.483、-0.58)为血清GAS6水平的独立影响因素。结论 T2DM患者血清GAS6水平低于NGT人群，BMI 、HbA1C、TNF-α与GAS6独立负相关。

　　【关键词】血清生长停滞特异性基因产物6;肥胖;糖尿病，2型

Analysis on the changes of serum GAS6 level and its related factors in T2DM patients CHEN Ling, CHENG Xing-bo. Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

Corresponding author: CHENG ming, E-mail:chenling1_2009@163.com

　　【Abstract】Objective To evaluate the association of serum growth arrest-specific gene 6 (GAS6) with T2DM and overweight. Methods Forty-two subjects with normal glucose tolerance (NGT) and forty-six patients with newly diagnosed T2DM were selected and each group was divided into normal weight and overweight subgroups according to BMI 18.5kg/m2 of serum GAS6 was measured by enzyme-linked immunosorbent assay. Results Compared with NGT group (14.27±3.82)ng/ml, the level of GAS6 in T2DM group (10.63±1.95)ng/ml was significantly lower (P<0.01). Correlation analysis showed that serum GAS6 was negatively correlated with BMI (r=-0.235), WC (r=-0.266), FBG (r=-0.362) , HbA1C (r=-0.427), C-RP ( r=-0.268), TNF-α (r=-0.442), and IL-6(r=-0.38), (P<0.05 or P<0.01), and positively with HDL-C (r=0.235), (P<0.05). Furthermore, multiple step-wise regression analysis showed that BMI, HbA1C, and TNF-α were the independent factors related to GAS6. Conclusion Serum GAS6 level in T2DM patients was lower, and it was negatively correlated with BMI, HbA1C, and TNF-α independently.

　　【Key words】Growth arrest-specific gene 6 (GAS6); Overweight; Diabetes mellitus, type 2