·糖尿病临床研究·

　　【摘要】 目的 分析血管紧张素原(AGT)基因rs7079(C/A)与福辛普利在伴高胰岛素血症的肥胖原发性高血压(EH)患者中降压疗效的相关性。方法70例伴高胰岛素血症的肥胖EH患者，以福辛普利(10 mg，1次/d)治疗，疗程4周。用PCR-限制性片段长度多态性的方法检测AGT基因rs7079(C/A)的基因型。分析其与降压效果及IS相关指标的关系。 结果 AGT基因rs7079(C/A)位点C、A等位基因频率分别为77.14%、22.86%，其中CC基因型患者43例、AA+AC基因型患者27例。与治疗前相比，两组基因型患者治疗4周后SBP、DBP均下降(P<0.05)，CC基因型患者SBP低于AC+AA基因型患者[(126.16±1.93)vs(133.00±2.40)mmHg，P<0.05]。未发现AGT基因rs7079(C/A)基因型与IS相关。结论 肥胖EH伴高胰岛素血症患者AGT基因rs7079(C/A)与福辛普利降压疗效相关，其中CC基因型患者降SBP效果更好。

　　【关键词】血管紧张素原;单核苷酸多态性;福辛普利;原发性高血压

Relationship between rs7079 in AGT gene and the response to Fosinopril treatment in essential hypertension patients with obesity and hyperinsulinimia LI Shi-rui, WANG Jia, LIU Xue-li, et al. Department of Endocrinology, China-Japan Friendship Hospital, Beijing100029, China

Corresponding author: XING Xiao-yan, E-mail: xingxy221@126.com

　　【Abstract】Objective To investigate the association of single-nucleotide polymorphisms (SNP) rs7079 (C/A) in the angiotensin (AGT) gene with the response to Fosinopril therapy in essential hypertension (EH) patients with obesity and hyperinsulinimia. Methods Seventy essential hypertension cases with obesity and hyperinsulinemia were recruited and treated with Fosinopril (10mg, once daily) for 4 weeks. Genotype of AGT rs7079 (C/A) was determined by PCR-restriction fragment length polymorphism (RFLP), and its relationship to blood pressure lowering effect of Fosinopril and insulin sensitivity was evaluated. Results The allelic frequency of C and A alleles in AGT rs7079 (C/A) was 77.14% and 22.86% respectively, corresponding to 43 cases with CC genotype and 27 cases with AA+AC genotypes. SBP and DBP in all the patients after the 4 weeks’ treatment were significantly decreased compared with those before the treatment (P<0.05). SBP of the patients with CC genotype was lower than those with AA+AC genotypes [(126.16±1.93) vs (133.00±2.40)mmHg, P<0.05] after the 4 weeks’ treatment. No association was detected between rs7079 (C/A) and insulin sensitivity related phenotype. Conclusion The genotype of rs7079 (C/A) in AGT gene is associated with the response to Fosinopril treatment in EH patients with obesity and hyperinsulinemia, and SBP of patients with CC genotype responds better to the treatment.

　　【Key words】 Angiotensin (AGT); Single-nucleotide polymorphisms (SNP); Fosinopril; Essential hypertension (EH)