·糖尿病基础研究·

　　【摘要】 目的 探讨白藜芦醇(Res)对高脂喂养小鼠β细胞的保护作用。 方法 随机分为正常对照(NC)组、高脂饮食(HF)组和Res干预(HR)组。比较糖脂代谢、β细胞形态功能及氧化应激的变化。 结果 HR组体内外胰岛素分泌功能明显改善，而糖脂代谢水平、β细胞量和氧化应激水平也较HF组明显下降。 结论 Res能纠正高脂饮食导致的胰岛功能异常，可能与胰腺内氧化应激损伤的改善有关。

　　【关键词】 白藜芦醇;糖尿病;胰岛β细胞

Resveratrol improves islet dysfunction in mice fed by high-fat Diet ZHANG Jiao-yue, CHEN Lu-lu, ZHENG Juan,et al. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Correspondence author: CHEN Lu-lu, E-mail: cheria_chen@126.com

　　【Abstract】 Objective To explore the protective effect of resveratrol on β cell in mice fed by a high-fat diet. Methods C57BL/6J mice were randomized into normal control (NC) group, high-fat diet (HF) group, and resveratrol treatment (HR) group. The HR group was fed the high fat diet for 8 weeks and then gaven intragastric administration of resveratrol 400mg/kg daily. At the end of the 24th week, the levels of glucose and lipid metabolism, the functions of insulin secretion, β cell mass and oxidative stress were measured. Results The functions of insulin secretion in vivo and in vitro were improved significantly in the HR group, while the levels of glucose and lipid metabolism, β cell mass and oxidative stress were lower than in the HF group. Conclusion Resveratrol can protect the mice from abnormal insulin secretion induced by high-fat diet. The effect might be related to the decreased oxidative stress of pancreas.

　　【Key words】 Resveratrol; Diabetes mellitus; Islet β cell