·糖尿病与心血管病·

　　【摘要】 目的 探讨女性糖尿病合并高血压对新发心脑血管事件的影响。方法 采用前瞻性队列研究方法，以参加体检的101510名开滦集团职工中1477例女性糖尿病患者作为观察对象，随访(48.05±3.09)个月。 结果 女性糖尿病合并高血压组的年龄、BMI、SBP、DBP、脉压、TG、UA、高敏C反应蛋白(hsC-RP)水平均高于血压正常组(P<0.01)。女性糖尿病合并高血压组总心脑血管事件、脑梗死、心肌梗死和脑出血事件累积发生率高于血压正常组，其中总心脑血管事件、脑梗死事件发生率差异有统计学意义(P<0.05)。女性糖尿病合并高血压组发生总心脑血管事件、脑梗死事件的风险分别为2.66倍(95%CI：1.33～5.30)和2.96倍(95%CI：1.13～7.79)。结论 女性糖尿病合并高血压可增加女性糖尿病患者新发心脑血管事件的风险。

　　【关键词】 糖尿病;高血压;心脑血管事件;女性

Effect of complicated hypertension in diabetic patients on new-onset cardio-cerebro-vascular events in women population LIU Xiu-rong, WU Shou-ling, SUN Yue-qiu, et al. The Affiliated Kailuan Hospital, Hebei United University, Tangshan 063000, China

Corresponding Author: WU Shou-ling, E-mail: drwusl@163.com

　　【Abstract】 Objective To evaluate the effect of complicated hypertension in diabetic patients on the new-onset cardio-cerebro-vascular events (CCVE) in women. Methods In this prospective cohort study, the 1477 women diabetic patients were selected from a total of 101510 employees of Kailuan Group for analysis. The follow-up lasted for 48.05±3.09 months. Results In the complicated hypertension diabetes group, the averaged age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, triglyceride (TG), urinary albumin (UA), and high sensitivity C-reaction protein (hsC-RP) were all higher than in the normal blood pressure diabetes group (P<0.01). In the complicated hypertension diabetes group, the incidence of total CCVE, cerebral infarction, myocardial infarction, and cerebral hemorrhage events was 4.6%, 2.6%, 1.0%, and 1.0% respectively, higher than that in the normal blood pressure diabetes group, of them, there was a statistical difference in the incidence of total CCVE and cerebral infarction events (P<0.05). Cox proportional hazard model showed the higher risk for the total CCVE, RR: 2.66，(95%CI: 1.33～5.30), and the cerebral infarction events, RR: 2.96, (95%CI: 1.13～7.79) for the female diabetic patients complicated with hypertension. Conclusion The risk of the new-onset cardio-cerebro-vascular events is higher in the female diabetic patients complicated with hypertension.

　　【Key words 】Diabetes; Hypertension; Cardio-cerebro-vascular events; Women, female