·糖尿病与大血管病变·

　　血清抵抗素、基质金属蛋白酶-2与2型糖尿病大血管病变相关性的研究

　　李丽疆 王海娇 吕少春 宋汉君

　　【摘要】 目的 探讨血清抵抗素和基质金属蛋白酶-2(MMP-2)与T2DM大血管病变的关系。方法 测定T2DM合并大血管病变(MVC)组、未合并大血管病变(T2DM)组及健康对照(NC)组的血清抵抗素、MMP-2和血清血管性血友病因子(vWF)水平。结果 T2DM组血清抵抗素、MMP-2、vWF水平高于NC组(P<0.01或P<0.05)，MCV组较T2DM组升高(P<0.01)。经多元逐步回归分析显示，MMP-2与SBP、vWF、LDL-C、HbA1c呈正相关(β=0.473、0.187、0.180、0.156，P<0.01或P<0.05);抵抗素与vWF、MMP-2、FPG呈正相关(β=0.486、0.351、0.189，P<0.01或P<0.05)。vWF与LDL-C、抵抗素、HbA1c、病程呈正相关(β=0.353、0.284、0.377、0.235，P<0.01)。 结论 MMP-2和抵抗素可与T2DM大血管并发症相关。

　　【关键词】糖尿病,2型;大血管病变;抵抗素;基质金属蛋白酶-2;血管性血友病因子

　　Association of resistin and matrix metalloproteinase-2 with T2DM macroangiopathy LI Li-jiang, WANG Hai-jiao, LV Shao-chun, et al. Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi 154003, China

　　Corresponding author: SONG Han-jun, E-mail: songhanjun1973@163.com

　　【Abstract】Objective To investigate the association of serum resistin and matrix metalloproteinase-2 (MMP-2) with T2DM macroangiopathy. Methods The serum resistin, MMP-2, and von Willebrand factor (vWF) were determined in 40 cases with macrovascular complications (MCV group), 40 cases without macrovascular complications (T2DM group), and 34 healthy controls(NC group). Results The serum resistin, MMP-2, and vWF were increased significantly in the T2DM group compared with those in the NC group (P<0.01 or P<0.05), and those in the MCV group were higher in comparing with the T2DM group (P<0.01). Multiple stepwise regression analysis showed that serum MMP-2 was correlated positively with SBP, vWF, LDL-C and HbA1c (β=0.473，0.187，0.180，0.156，P<0.01 or P<0.05); Resistin was correlated positively with vWF, MMP-2, and FPG (β=0.486, 0.351, 0.189, P<0.01 or P<0.05); and vWF was correlated positively with LDL-C, resistin, HbA1c, and the course of diabetes (β=0.353, 0.284, 0.377, 0.235, P<0.01). Conclusion MMP-2 and resistin can influence each other and jointly promote the development and progression of T2DM macroangiopathy.

　　【Key words】Diabetes mellitus, type2; Macroangiopathy; Resistin; Matrix metalloproteinase-2 (MMP-2); von Willebrand factor (vWF)