·糖尿病与心脏病·

　　糖代谢异常合并冠心病患者平均血小板体积变化及其影响因素的研究

　　许文亮 惠波 王旭 邵一兵

　　【摘要】 目的 观察冠心病合并糖代谢异常(AGM)患者平均血小板体积(MPV)的变化及其影响因素。 方法 选取冠心病患者139例(CHD组)，其中，合并T2DM者46例(T2DM组)，糖耐量减低(IGT组)者38例，无AGM者(NAGM组)55例。另选21名正常健康人群为健康对照(NC)组。均测定MPV等参数。 结果 CHD组MPV高于NC组(P<0.05);T2DM组MPV高于NC组和NAGM组(P<0.01);IGT组MPV显著高于NC组(P<0.01)。冠心病合并AGM患者MPV高值组BMI、2 hPG、HbA1c和尿微量白蛋白(U-MA)高于低值组(P<0.05)。HbA1c和BMI是MPV的独立影响因素。 结论 冠心病合并AGM患者MPV升高，BMI、2 hPG、HbA1c和U-MA与其升高有关，HbA1c和BMI是MPV的独立影响因素。

　　【关键词】 平均血小板体积;冠心病;糖代谢异常

　　Mean platelet volume and its influenced factors in coronary artery disease patients with abnormal glucose metabolism XU Wen-liang, HUI Bo, WANG Xu, et al. Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, China

　　Corresponding author: HUI Bo, E-mail: huibo6910@eyou.com

　　【Abstract】 Objective To detect the changes of mean platelet volume (MPV) in CAD patients with abnormal glucose metabolism (AGM). Methods MPV was measured in 139 CAD patients, including 46 with T2DM (T2DM group), 38 with impaired glucose tolerance (IGT group), and 55 without AGM (NAGM group). Twenty-one healthy people were enrolled as the normal controls. Results The MPV in CAD patients was higher than in the controls (P<0.01). The patients with T2DM had increased MPV compared to controls and patients without AGM (all P<0.01). The patients with IGT showed enhanced MPV than the controls (P<0.01). BMI, 2hPG, HbA1c, and U-MA were higher in the MPV high group than in the low group in AGM patients (all P<0.05). HbA1c and BMI were the independent predictors of MPV. Conclusion The MPV is increased in CAD patients with AGM. BMI, 2hPG, HbA1c and U-MA are associated with the elevated MPV. HbA1c and BMI are the predictors of MPV.

　　【Key words】 Mean platelet value (MPV); Coronary artery disease (CAD); Abnormal glucose metabolism (AGM)